INT208919

Context Info Confidence 0.09 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.73 Pain Relevance 0.11

nucleus (Fli1) DNA binding (Fli1)

Anatomy Link Frequency GCT 1 Fli1 (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 1 98.84 Inflammation 28 73.52 substance P 22 5.00 antagonist 5 5.00 Inflammatory response 4 5.00 Pain 3 5.00 Inflammatory mediators 2 5.00 interstitial cystitis 2 5.00 imagery 2 5.00 Lasting pain 1 5.00

Disease Link Frequency Relevance Heat Cancer 12 99.20 Shock 2 93.02 Adhesions 1 87.28 Apoptosis 3 85.98 INFLAMMATION 33 73.52 Death 3 63.92 Primitive Neuroectodermal Tumors 27 50.00 Sarcoma 27 50.00 Malignant Neoplastic Disease 3 30.56 Lymphadenopathy 3 27.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

l from the reaction was PCR amplified using EWS 22.3 forward primer (5'-TCC TAC AGC CAA GCT CCA AGT C-3') and FLI1 11.3 reverse primer (5'-ACT CCC CGT TGG TCC CCT CC-3') in a 20-?

Regulation (using) of FLI1 in GCT

1) Confidence 0.09 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2848680 Disease Relevance 0 Pain Relevance 0

Overall NK1R-dependent genes were classified following the biological processes with which they are involved (GO anthology): apoptosis (GZMA, TNFRSF1B, TNFRSF1A, TRAF3, NOS2A, and BID); cell adhesion/hyaluronic acid binding (CD44 and AGC1); cell cycle (CCND2 and CCNG1); cell-cell signaling (FGF11 and GJA7); cytokinesis (CDC42 and KIF1B); development (FMR2); extracellular transporters & carriers (APOE); G-protein coupled receptors (GNA13 and PTGIR); growth factors (MXD1); heat shock proteins (PRNP, HSPH1, and HSPD1); immune response (BST-1, CTSW, and IL1R1); interferons (INFGR1) intracellular kinases (WBP6); intracellular transducers (MAP3K7); kinase activators & inhibitors (YWHAH); membrane channels (KCNAB1, KCNJ12, KCNQ1, and SLC30A4); nucleotide metabolism (PCSK1); oncogenes & tumor suppressors (BRCA1, MAP3K8, RET, VIL2, FLI1, MET, NF2, and VEGFR1); receptor mediated endocytosis (DAB2); receptor tyrosine kinase (EPHA2); regulation of transcription (NEUROD6); serotonin biosynthesis (YTPH1); symporters & antiporters (SLC16A1 and SLC1A1); transcription activators & repressors (FOXA1, HSF1, IER2, and NR1H2); and synaptic transmission (GRID1).

Regulation (regulation) of FLI1 associated with cancer, shock, apoptosis, serotonin and adhesions

2) Confidence 0.05 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.73 Pain Relevance 0.11

General Comments

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