INT208983

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1) response to stress (Ca2)
Anatomy Link Frequency
neurons 1
Ca2 (Rattus norvegicus)
Kcnma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
TRP channel 6 70.76 Quite High
Inflammation 10 59.04 Quite High
Pain 24 50.00 Quite Low
agonist 7 11.20 Low Low
qutenza 27 5.00 Very Low Very Low Very Low
antagonist 22 5.00 Very Low Very Low Very Low
cva 11 5.00 Very Low Very Low Very Low
Endep 10 5.00 Very Low Very Low Very Low
Dorsal horn neuron 8 5.00 Very Low Very Low Very Low
IPN 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 4 94.40 High High
Drug Induced Neurotoxicity 5 73.88 Quite High
INFLAMMATION 11 59.04 Quite High
Apoptosis 7 57.00 Quite High
Pain 23 50.00 Quite Low
Pressure And Volume Under Development 1 41.84 Quite Low
Stroke 21 36.28 Quite Low
Cv General 4 Under Development 10 5.00 Very Low Very Low Very Low
Nociception 8 5.00 Very Low Very Low Very Low
Inflammatory Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(ii) In neurons, different KCa channels can couple to different sources of intracellular Ca2+ [69], possibly in microdomains comprised of different macromolecular signaling complexes [25,70].
Ca2 Binding (couple) of KCa in neurons
1) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.19 Pain Relevance 0.03
In general, either disruption of a TRP-Ca2+-channel interaction or block of Ca2+-feedback by anti- calmodulin agents can deregulate store operated Ca2+ entry and cause eventually excitotoxicity and cell death by Ca2+-overload [24], [25].
Ca2 Binding (interaction) of channel associated with death
2) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0.09 Pain Relevance 0.07

General Comments

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