INT209434

Context Info Confidence 0.10 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1) cytoplasm (Col1a1)

Anatomy Link Frequency urine 2 Col1a1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 1 9.60 cytokine 4 5.00 withdrawal 3 5.00 ketamine 1 5.00 anesthesia 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Hypercalcemia 10 5.00 Osteopetrosis 6 5.00 Osteoporosis 3 5.00 Disease 3 5.00 Aging 2 5.00 Postmenopausal Osteoporosis 1 5.00 Targeted Disruption 1 5.00 Rheumatoid Arthritis 1 5.00 Endometriosis (extended) 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This phenotype is mostly due to impairment of osteoclast function, since the number of osteoclasts counted on bone surfaces was similar for all four backgrounds (Figure 4B), while collagen type I degradation products present in the urine of 12-week-old DKO female mice had decreased by 17% compared with WT females (Figure 4C).

Negative_regulation (decreased) of Protein_catabolism (degradation) of collagen type I in urine

1) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0

General Comments

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