INT209882

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.82
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) extracellular space (IL4) extracellular region (IL4)
cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
neutrophils 4
IL4 (Homo sapiens)
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 116 97.56 Very High Very High Very High
Osteoarthritis 20 91.92 High High
Inflammation 62 80.64 Quite High
Arthritis 8 55.12 Quite High
cytokine 24 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 18 99.88 Very High Very High Very High
Necrosis 18 99.64 Very High Very High Very High
Rheumatoid Arthritis 116 97.56 Very High Very High Very High
Osteoarthritis 20 91.92 High High
INFLAMMATION 60 80.64 Quite High
Arthritis 6 55.12 Quite High
Apoptosis 16 5.00 Very Low Very Low Very Low
Osteoporosis 6 5.00 Very Low Very Low Very Low
Hypercalcemia 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, healthy human blood neutrophils can be induced to express RANK and OPG in response to different stimuli such as IL-4+TNF-?
IL-4 Positive_regulation (induced) of Gene_expression (express) of RANK in neutrophils
1) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.57 Pain Relevance 0.28
The expression of OPG and RANK by normal human blood neutrophils, however, can be induced by interleukin-4 + tumor necrosis factor-alpha and by SFs from patients with RA.
interleukin-4 Positive_regulation (induced) of Gene_expression (expression) of RANK in neutrophils associated with necrosis, cancer and rheumatoid arthritis
2) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906801 Disease Relevance 1.25 Pain Relevance 0.48

General Comments

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