INT209887

Context Info Confidence 0.43 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.41 Pain Relevance 0.29

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 16 93.20 rheumatoid arthritis 58 84.28 Bioavailability 1 77.36 Osteoarthritis 76 61.16 Inflammation 35 5.00 Arthritis 5 5.00 cINOD 2 5.00 Pain 2 5.00 Paracetamol 1 5.00 psoriasis 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 58 84.28 Apoptosis 9 82.36 Osteoarthritis 76 61.16 Osteoporosis 19 44.44 Hypercalcemia 9 27.72 INFLAMMATION 35 5.00 Necrosis 10 5.00 Cancer 10 5.00 Disease 8 5.00 Arthritis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the OPG and RANKL system, our data revealed that CS can modulate the expression of these molecules by increasing OPG and decreasing the gene expression level of RANKL, thereby increasing the mRNA ratio of OPG/RANKL.

Positive_regulation (increasing) of Transcription (ratio) of OPG

1) Confidence 0.43 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.06 Pain Relevance 0.07

The expression of OPG mRNA, which was absent at day 0 (Figure 1a), significantly increased at days 1, 2, and 3 (Figure 3).

Positive_regulation (increased) of Transcription (expression) of OPG

2) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.35 Pain Relevance 0.22

General Comments

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