INT209896

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 11.90
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD80) intracellular (CD80) cell-cell signaling (CD80)
Anatomy Link Frequency
CD86 19
macrophages 4
T lymphocytes 4
blood 2
B cells 2
CD80 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 172 100.00 Very High Very High Very High
Central nervous system 17 96.92 Very High Very High Very High
chemokine 54 89.92 High High
tolerance 22 86.56 High High
rheumatoid arthritis 62 83.20 Quite High
cINOD 9 81.52 Quite High
corticosteroid 27 80.32 Quite High
Inflammation 165 80.24 Quite High
Inflammatory mediators 4 73.36 Quite High
psoriasis 3 69.68 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 150 99.24 Very High Very High Very High
Cancer 469 99.18 Very High Very High Very High
Skin Cancer 92 98.76 Very High Very High Very High
Infection 464 98.72 Very High Very High Very High
Helminth Infection 12 98.22 Very High Very High Very High
Renal Cancer 12 97.90 Very High Very High Very High
Occupational Lung Diseases 18 97.32 Very High Very High Very High
Hookworm Infection 105 97.06 Very High Very High Very High
Hypersensitivity 10 96.88 Very High Very High Very High
Neurocysticercosis 30 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently observed that O3 exposure can also result in increased expression of CD11b, CD14, CD16, CD80, CD86, and HLA-DR on airway dendritic cells (DCs), monocytes, and macrophages (Alexis et al. 2004b).
Positive_regulation (result) of in CD86 Gene_expression (expression) of CD80 in macrophages
1) Confidence 0.49 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 1.13 Pain Relevance 0.14
We have recently observed that O3 exposure can also result in increased expression of CD11b, CD14, CD16, CD80, CD86, and HLA-DR on airway dendritic cells (DCs), monocytes, and macrophages (Alexis et al. 2004b).
Positive_regulation (increased) of Gene_expression (expression) of CD80 in macrophages
2) Confidence 0.49 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 1.13 Pain Relevance 0.14
In vivo suppression also requires B7 expression on effector cells.
Positive_regulation (requires) of Gene_expression (expression) of B7
3) Confidence 0.43 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.04
However, here we demonstrated that hookworm ES products may be partially responsible for the alternative differentiation of DC, as observed by the reduction of CD11c and CD86 expression and increase of CD80 expression on the DC surface.
Positive_regulation (increase) of Gene_expression (expression) of CD80 in CD86 associated with hookworm infection
4) Confidence 0.43 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.48 Pain Relevance 0.12
CD40 stimulation triggers important signals for antibody production by B cells and strongly induces B7 and MHC expression on APCs.
Positive_regulation (induces) of Gene_expression (expression) of B7 in B cells
5) Confidence 0.31 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
Monocyte-derived dendritic cells differentiated in the presence of N. americanus excreted-secreted products both from adult worm (ESAw) and L3 larvae (ESL3) showed a significant decreased expression of CD11c and CD86 while presented higher expression of CD80 (Fig 2).
Positive_regulation (higher) of Gene_expression (expression) of CD80 in CD86 associated with helminth infection
6) Confidence 0.31 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.40 Pain Relevance 0
Monocyte-derived dendritic cells differentiated in the presence of N. americanus excreted-secreted products both from adult worm (ESAw) and L3 larvae (ESL3) showed a significant decreased expression of CD11c and CD86 while presented higher expression of CD80 (Fig 2).
Positive_regulation (presented) of Gene_expression (expression) of CD80 in CD86 associated with helminth infection
7) Confidence 0.31 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.40 Pain Relevance 0
In addition, phlogogenic cytokines activate neutrophils to express CCR6, CD80, CD83, CD86, and CD40, an expression pattern that resembles a dendritic-like phenotype [10,11].
Positive_regulation (activate) of Gene_expression (express) of CD80 in CD86 associated with cytokine
8) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 1.15 Pain Relevance 0.55
At day 7 of treatment, the elevated CD80 expression by PDCs (Fig.
Positive_regulation (elevated) of Gene_expression (expression) of CD80
9) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 0.25 Pain Relevance 0
A majority of CCR7+ mDC in progressor animals also expressed CD86 with a smaller proportion expressing CD80, consistent with activation (Figure 3E).
Positive_regulation (proportion) of Gene_expression (expressing) of CD80 in CD86
10) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.78 Pain Relevance 0.04
PolyIC was shown to effectively block HIV replication in DCs in vitro [22], to upregulate CD80 expression on blood mDCs in vivo following tonsillar application (E.
Positive_regulation (upregulate) of Gene_expression (expression) of CD80 in blood associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943484 Disease Relevance 0.38 Pain Relevance 0.03
We have recently observed that O3 exposure can also result in increased expression of CD11b, CD14, CD16, CD80, CD86, and HLA-DR on airway dendritic cells (DCs), monocytes, and macrophages (Alexis et al. 2004b).
Positive_regulation (increased) of in monocytes Gene_expression (expression) of CD80 in macrophages
12) Confidence 0.17 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 1.13 Pain Relevance 0.14
Expression of the costimulatory molecules CD80 and CD86 was markedly increased in all animals at 2 weeks post infection indicative of rapid mDC activation (Figure 3A–D).
Positive_regulation (increased) of Gene_expression (Expression) of CD80 in CD86 associated with infection
13) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.95 Pain Relevance 0.04
DCs maturation was evidenced by increased expression of CD83, CD80, CD86, HLA class I and II and CD40.
Positive_regulation (increased) of Gene_expression (expression) of CD80 in CD86
14) Confidence 0.15 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.13 Pain Relevance 0.04
Immature DCs efficiently phagocytosed melanoma Apo-Nec cells and matured after phagocytosis as evidenced by increased expression of CD83, CD80, CD86, HLA class I and II, and 75.2 ± 16% reduction in Dextran-FITC endocytosis.
Positive_regulation (increased) of Gene_expression (expression) of CD80 in CD86 associated with skin cancer
15) Confidence 0.14 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2265680 Disease Relevance 0.86 Pain Relevance 0
In renal cell carcinoma, its expression has been correlated with more aggressive tumors, particularly in those cases where both B7-H1 and B7-H4 are aberrantly overexpressed [99].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of B7 associated with cancer and renal cancer
16) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.79 Pain Relevance 0
Likewise, dendritic cells stimulated with helminth components show limited upregulation of CD80, CD86 and MHC-II expression in comparison to the expression induced by bacterial antigens [37].
Positive_regulation (upregulation) of Gene_expression (expression) of CD80 in CD86
17) Confidence 0.10 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.67 Pain Relevance 0.09
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
Positive_regulation (induce) of Gene_expression (expression) of CD80 in T lymphocytes associated with cytokine
18) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.27 Pain Relevance 0.11
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
Positive_regulation (activation) of Gene_expression (expression) of CD80 in T lymphocytes associated with cytokine
19) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.27 Pain Relevance 0.11
In renal cell carcinoma, its expression has been correlated with more aggressive tumors, particularly in those cases where both B7-H1 and B7-H4 are aberrantly overexpressed [99].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of B7 associated with cancer and renal cancer
20) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.74 Pain Relevance 0

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