INT21011

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Context Info
Confidence 0.37
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.58
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2RY6) signal transducer activity (P2RY6)
Anatomy Link Frequency
nasal 2
endothelial cells 1
osteoclasts 1
corneal epithelial cell 1
P2RY6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 99.64 Very High Very High Very High
agonist 26 98.24 Very High Very High Very High
addiction 1 96.52 Very High Very High Very High
antagonist 32 91.52 High High
Serotonin 4 90.68 High High
cytokine 87 86.24 High High
Inflammatory mediators 1 83.24 Quite High
Multiple sclerosis 2 82.56 Quite High
cva 2 78.24 Quite High
fibrosis 1 76.04 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 6 99.64 Very High Very High Very High
Adhesions 6 99.00 Very High Very High Very High
Pancreatic Cancer 4 98.64 Very High Very High Very High
Disease 25 96.48 Very High Very High Very High
Wound Healing 27 91.12 High High
Stress 17 90.80 High High
Sepsis 1 83.56 Quite High
INFLAMMATION 47 82.84 Quite High
Demyelinating Disease 2 82.56 Quite High
Atherosclerotic Plaque 1 80.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcripts of ectonucleotidases (CD39 and CD39L1) together with P2R (P2X7, P2Y2, and P2Y6) are significantly increased in both chronic pancreatitis and pancreatic cancer.
Positive_regulation (increased) of P2Y6 associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.37 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.43 Pain Relevance 0.43
UTP and ATP stimulate expression of proinflammatory vascular cell adhesion molecule-1 (VCAM-1) in endothelial cells through activation of the P2Y2 receptor and increases the adherence of monocytic cells to human coronary endothelial cells, an effect that was inhibited by anti-VCAM-1 antibodies [119].
Positive_regulation (activation) of P2Y2 receptor in endothelial cells associated with adhesions
2) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.84 Pain Relevance 0.12
In osteoclasts, activation of the P2Y6 receptor via UDP or the selective receptor agonist INS48823 induces a transient rise in intracellular Ca2+ and activation of the transcription factor NF-?
Positive_regulation (activation) of P2Y6 in osteoclasts associated with agonist
3) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.27 Pain Relevance 0.40
Pyrimidinergic receptor P2Y6 (p2ry6) is expressed in human nasal epithelial cells and activates the IP3 signaling pathway in the presence of UDP, and regulates mucin and fluid secretion [49].
Positive_regulation (activates) of p2ry6 in nasal
4) Confidence 0.27 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2556351 Disease Relevance 0.22 Pain Relevance 0.12
Pyrimidinergic receptor P2Y6 (p2ry6) is expressed in human nasal epithelial cells and activates the IP3 signaling pathway in the presence of UDP, and regulates mucin and fluid secretion [49].
Positive_regulation (activates) of Pyrimidinergic receptor P2Y6 in nasal
5) Confidence 0.27 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2556351 Disease Relevance 0.22 Pain Relevance 0.12
It has been tentatively suggested that the activation of P2Y2 receptors accelerates the rate of corneal epithelial cell migration while the stimulation of a P2Y6 does the opposite [6].
Positive_regulation (stimulation) of P2Y6 in corneal epithelial cell
6) Confidence 0.23 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.59 Pain Relevance 0.08
These effects were considered to be related to P2-purinoceptor activation.
Positive_regulation (activation) of P2-purinoceptor
7) Confidence 0.14 Published 1990 Journal Pflugers Arch. Section Abstract Doc Link 2162032 Disease Relevance 0 Pain Relevance 0.12

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