INT210391

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.51
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT1) Golgi apparatus (FUT1) carbohydrate metabolic process (FUT1)
Anatomy Link Frequency
liver 2
FUT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 32 98.82 Very High Very High Very High
antagonist 9 86.20 High High
cytokine 8 79.16 Quite High
Inflammation 29 55.44 Quite High
Chronic pancreatitis 9 16.08 Low Low
cva 17 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 376 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 31 99.76 Very High Very High Very High
Disease 61 99.36 Very High Very High Very High
Apoptosis 42 98.80 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 158 98.46 Very High Very High Very High
Fibrosis 30 96.96 Very High Very High Very High
Hematological Disease 14 90.36 High High
Liver Disease 3 87.20 High High
Syndrome 4 83.92 Quite High
Congenital Anomalies 7 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found collagen type 11a1 expression to be highly specific for the PSC and almost absent in HSC.
Negative_regulation (absent) of HSC associated with cirrhosis and primary sclerosing cholangitis
1) Confidence 0.20 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.20 Pain Relevance 0
In experimental liver fibrosis, resolution of the disease was found to be accompanied by loss of HSC via spontaneous induction of apoptosis in these cells (14,15).
Negative_regulation (loss) of HSC in liver associated with fibrosis, cirrhosis, apoptosis and disease
2) Confidence 0.17 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.85 Pain Relevance 0.15
In Fig. 1 it can be seen that binding of 125I–15dPGJ2-M6PHSA to HSC was significantly reduced by 81?
Negative_regulation (reduced) of HSC associated with cirrhosis
3) Confidence 0.12 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.53 Pain Relevance 0.08
The expression of a scavenger receptor class B, CD36, was reported on HSC and a co-localisation with alpha-smooth muscle actin-positive HSC in human fibrotic livers was immunohistochemically demonstrated (30).
Negative_regulation (reported) of HSC in livers associated with fibrosis and cirrhosis
4) Confidence 0.12 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.79 Pain Relevance 0
As mentioned above, PNH is a true disease of the HSC, as marked by the PIG-A mutation; however, the HSC defect does not entirely explain the phenotype.
Negative_regulation (defect) of HSC associated with paroxysmal nocturnal hemoglobinuria and disease
5) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.15 Pain Relevance 0

General Comments

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