INT21046

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2009
Negated 0
Speculated 1
Reported most in Title
Documents 3
Total Number 4
Disease Relevance 0.09
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
NASh 2
neurons 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 5 100.00 Very High Very High Very High
dopamine receptor 3 100.00 Very High Very High Very High
Morphine 18 99.82 Very High Very High Very High
Opioid receptor 1 1 96.88 Very High Very High Very High
Opioid 2 94.56 High High
Dopamine 9 86.20 High High
Enkephalin 2 85.48 High High
agonist 5 84.68 Quite High
Nucleus accumbens 4 79.44 Quite High
gABA 3 74.08 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 1 86.64 High High
Hyperphagia 1 33.24 Quite Low
Morphine Dependence 1 5.00 Very Low Very Low Very Low
Eating Disorder 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When combined, the individual effects of D1 receptor activation in the NASh and VTA on the affective signs of precipitated morphine withdrawal resemble those seen with systemic administration.


Regulation (effects) of Positive_regulation (activation) of D1 receptor in NASh
1) Confidence 0.44 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 19148621 Disease Relevance 0 Pain Relevance 0
Morphine-induced increase in D-1 receptor regulated signal transduction in rat striatal neurons and its facilitation by glucocorticoid receptor activation: possible role in behavioral sensitization.
Regulation (regulated) of Spec (possible) Positive_regulation (increase) of D-1 receptor in neurons associated with morphine
2) Confidence 0.38 Published 1996 Journal Neurochem. Res. Section Title Doc Link 8947932 Disease Relevance 0 Pain Relevance 0.69
Role of opiates in striatal D-1 dopamine receptor supersensitivity induced by chronic L-dopa treatment.
Regulation (Role) of Positive_regulation (induced) of D-1 dopamine receptor associated with dopamine receptor and opiate
3) Confidence 0.17 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2162953 Disease Relevance 0.09 Pain Relevance 0.52
Its expression, however, involves both opiate and D-1 receptor activation.
Regulation (involves) of Positive_regulation (activation) of D-1 receptor associated with opiate
4) Confidence 0.16 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10989273 Disease Relevance 0 Pain Relevance 0.85

General Comments

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