INT210590

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 8.09
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Mip) plasma membrane (Mip) transmembrane transport (Mip)
Anatomy Link Frequency
lung 4
macrophages 2
diaphragm 2
T cell 2
Mip (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 121 100.00 Very High Very High Very High
chemokine 242 99.66 Very High Very High Very High
cytokine 97 91.84 High High
Pain 4 89.12 High High
antagonist 5 64.00 Quite High
Inflammatory response 13 58.56 Quite High
tolerance 1 20.56 Low Low
Inflammatory stimuli 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 137 100.00 Very High Very High Very High
Infection 140 99.98 Very High Very High Very High
Candida Infection 137 99.98 Very High Very High Very High
Endotoxemia 54 99.36 Very High Very High Very High
Sprains And Strains 62 99.32 Very High Very High Very High
Muscular Dystrophy 6 97.82 Very High Very High Very High
Solid Tumor 3 97.44 Very High Very High Very High
Sepsis 156 97.04 Very High Very High Very High
Hypersensitivity 28 96.72 Very High Very High Very High
Reprotox - General 1 1 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The major findings of our study can be summarized as follows: (1) diaphragmatic CCR1 gene expression is upregulated in response to acute endotoxemia; (2) both acute endotoxemia and Pseudomonas lung infection lead to increased expression of the CCR1 ligands, RANTES and MIP-1?
Positive_regulation (lead) of Gene_expression (expression) of MIP in lung associated with endotoxemia and infection
1) Confidence 0.67 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.74 Pain Relevance 0.23
The major findings of our study can be summarized as follows: (1) diaphragmatic CCR1 gene expression is upregulated in response to acute endotoxemia; (2) both acute endotoxemia and Pseudomonas lung infection lead to increased expression of the CCR1 ligands, RANTES and MIP-1?
Positive_regulation (increased) of Gene_expression (expression) of MIP in lung associated with endotoxemia and infection
2) Confidence 0.67 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.73 Pain Relevance 0.23
The observation that an intact RANK signaling pathway is indispensable for the osteoclastogenic effect of MIP-1?
Positive_regulation (indispensable) of Gene_expression (effect) of MIP
3) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.29 Pain Relevance 0.03
Pulmonary exposure to CSBG elevated the levels of MIP-1?
Positive_regulation (elevated) of Gene_expression (levels) of MIP associated with candida infection
4) Confidence 0.49 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.37 Pain Relevance 0.31
For example, in the mdx mouse, a murine model of Duchenne muscular dystrophy, the diaphragm exhibits a pronounced infiltration by macrophages and lymphocyctes, which parallels a marked overexpression of RANTES and MIP-1?
Positive_regulation (overexpression) of Gene_expression (overexpression) of MIP in macrophages associated with muscular dystrophy
5) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.91 Pain Relevance 0.29
Figure 2 shows that the overall patterns of RANTES and MIP-1?
Positive_regulation (overall) of Gene_expression (overall) of MIP
6) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.08 Pain Relevance 0.08
Here we sought to study the local expression and
                             molecular regulation of the chemokines, regulated upon activation
                             normal T cell expressed and secreted (RANTES) and macrophage
                             inflammatory protein (MIP)-1?
Positive_regulation (activation) of Gene_expression (expressed) of MIP in T cell associated with chemokine and inflammation
7) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.83 Pain Relevance 0.23
We next sought to evaluate whether the observed upregulation of CCRs in the septic diaphragm and TA is associated with altered expression of their cognate ligands, RANTES and MIP-1?
Spec (whether) Positive_regulation (associated) of Gene_expression (expression) of MIP in diaphragm
8) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.09 Pain Relevance 0.07
A significant increase in the expression of MCP-1, MIP-1?
Positive_regulation (increase) of Gene_expression (expression) of MIP
9) Confidence 0.45 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.95 Pain Relevance 0.13
The subgroup of aquaporins is composed of AQP0, AQP1, AQP2, AQP4, AQP5, AQP6 and AQP8 and is considered to be mainly permeable to water with a high flow rate.
Positive_regulation (subgroup) of Gene_expression (composed) of AQP0
10) Confidence 0.14 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0 Pain Relevance 0
A mutation in MIP, a gene coding for the catalytic subunit of yeast POLG, results in mtDNA depletion and formation of petite rho0 cells (5).
Positive_regulation (results) of Gene_expression (mutation) of MIP
11) Confidence 0.07 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 1.09 Pain Relevance 0.09

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