INT210833

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.57
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc4r) plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
body 2
Mc4r (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 19 99.58 Very High Very High Very High
Inflammation 21 98.60 Very High Very High Very High
Hyperalgesia 7 96.72 Very High Very High Very High
allodynia 12 95.36 Very High Very High Very High
medulla 27 92.16 High High
melanocortin 1 receptor 70 89.92 High High
vagus nerve 7 82.04 Quite High
Cholecystokinin 8 81.48 Quite High
agonist 45 76.00 Quite High
Endogenous opioid 2 73.12 Quite High
Disease Link Frequency Relevance Heat
Body Weight 15 100.00 Very High Very High Very High
Obesity 87 99.12 Very High Very High Very High
INFLAMMATION 22 98.60 Very High Very High Very High
Hyperalgesia 13 96.72 Very High Very High Very High
Neuropathic Pain 22 95.36 Very High Very High Very High
Anorexia 14 79.48 Quite High
Injury 18 66.28 Quite High
Nociception 13 54.12 Quite High
Pain 24 50.00 Quite Low
Inflammatory Pain 9 44.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of MC4R in reducing the formalin response cannot be ruled out in the Ay-Jkn1 mice; indeed the second phase of the formalin response has been shown to be attenuated by antagonists that preferentially act on MC4R [41].
Regulation (act) of MC4R associated with antagonist
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 0.81 Pain Relevance 0.84
Using immunocytochemistry to demonstrate both POMC and AgRP fibres and in situ hybridisation to show their MC4R and MC3R targets (Table 3), much of the neuroanatomy of the melanocortin system has been mapped [93].
Regulation (targets) of MC4R
2) Confidence 0.27 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.17 Pain Relevance 0.96
The melanocortin-4 receptor (MC4R) is primarily expressed in the mammalian brain, plays an important role in body weight regulation [20], and is a lead target for the treatment of obesity [21].
Regulation (target) of melanocortin-4 receptor in body associated with body weight and obesity
3) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0.30 Pain Relevance 0.29
The melanocortin-4 receptor (MC4R) is primarily expressed in the mammalian brain, plays an important role in body weight regulation [20], and is a lead target for the treatment of obesity [21].
Regulation (target) of MC4R in body associated with body weight and obesity
4) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0.30 Pain Relevance 0.29

General Comments

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