INT210938

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.42
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
plasma 2
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 98.58 Very High Very High Very High
rheumatoid arthritis 82 94.92 High High
corticosteroid 8 41.44 Quite Low
alcohol 1 22.40 Low Low
Infliximab 12 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Etanercept 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 94 100.00 Very High Very High Very High
Disease 36 100.00 Very High Very High Very High
INFLAMMATION 16 98.58 Very High Very High Very High
Hyperlipidemia 8 97.56 Very High Very High Very High
Obesity 25 96.56 Very High Very High Very High
Rheumatoid Arthritis 84 94.92 High High
Atherosclerosis 7 91.92 High High
Cardiovascular Disease 16 81.00 Quite High
Diabetes Mellitus 3 61.00 Quite High
Coronary Heart Disease 7 48.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies, like ours, reveal a significant influence of moderate continuous exercise on lipids and lipoprotein fraction concentrations and composition, implying that exercise may enhance HDL-c fractions, and utilization and degradation of triglycerides and cholesterol, which increases the uptake of low-density lipoprotein and lowers plasma lipid levels, consequently underlining the role of exercise in the treatment and risk reduction of hypercholesterolemia and obesity [20-22].
Spec (may) Positive_regulation (enhance) of HDL Binding (underlining) of in plasma associated with obesity, hyperlipidemia and disorder of lipid metabolism
1) Confidence 0.49 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1933532 Disease Relevance 0.79 Pain Relevance 0
In addition, inflammation leads to pro-atherogenic changes of the lipoprotein metabolism and an increased disease activity is associated with lower TC levels and even more depressed HDL-C levels and lowered apo A1 levels.
Positive_regulation (increased) of HDL Binding (associated) of associated with inflammation, disease and disorder of lipid metabolism
2) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350142 Disease Relevance 1.63 Pain Relevance 0.44

General Comments

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