INT210990

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.60 Pain Relevance 0.19

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)

Anatomy Link Frequency testis 2 KCNMA1 (Homo sapiens) PKDREJ (Homo sapiens)

Pain Link Frequency Relevance Heat TRP channel 4 100.00 Mechanotransduction 2 5.00 member 8 2 5.00

Disease Link Frequency Relevance Heat Polycystic Kidney Disease 16 67.56 Renal Failure 2 66.24 Cyst 2 64.72 Disease 20 60.48 Autosomal Dominant Polycystic Kidney 6 57.84 Stress 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Like hPKDREJ, SpREJ3 also associates with a sea urchin sperm TRP channel, SpPKD2 [22]. hPKD1-like-1 (hPKD1L1) has high expression levels in testis Leydig cells and heart [23]. hPKD1L2 is found in a long and short form, the short form beginning in exon 12 of the long form.

channel Binding (associates) of hPKDREJ in testis associated with trp channel

1) Confidence 0.00 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0.17 Pain Relevance 0.10

The intronless hPKDREJ is only expressed in mammalian testis [19] and associates with several TRP channel proteins and modulates G-protein signaling [20].

channel Binding (associates) of hPKDREJ in testis associated with trp channel

2) Confidence 0.00 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0.43 Pain Relevance 0.09

General Comments

This test has worked.