INT211030

Context Info Confidence 0.45 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.62 Pain Relevance 0.35

mRNA binding (Celf4) mRNA processing (Celf4) RNA binding (Celf4) nucleus (Celf4) cytoplasm (Celf4)

Anatomy Link Frequency neuronal 1 brain 1 Atlas 1 Celf4 (Mus musculus)

Pain Link Frequency Relevance Heat Neuronal excitability 3 98.96 Hippocampus 30 96.08 Serotonin 9 89.92 Pyramidal cell 9 76.44 cerebral cortex 6 65.72 fluoxetine 6 5.00 Analgesic 3 5.00 Neurotransmitter 3 5.00

Disease Link Frequency Relevance Heat Convulsion 159 91.32 Neurodegenerative Disease 3 85.32 Obesity 3 61.96 Attention Deficit Hyperactivity Disorder 6 61.04 Epilepsy 63 50.00 Targeted Disruption 21 47.20 Absence Epilepsy 15 43.00 Disease 15 27.76 Inborn Genetic Diseases 3 26.32 Sprains And Strains 27 14.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, we cannot ignore other genes misregulated in Brunol4 mutants, some with unknown function (Table S1), since many also expressed selectively within the hippocampus in B6 mice (Allen Brain Atlas [32]).

Regulation (misregulated) of Brunol4 in Atlas associated with hippocampus

1) Confidence 0.45 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.27 Pain Relevance 0.12

Thus, in the absence or reduction of BRUNOL4, these molecules become dysregulated, leading to imbalance in neuronal excitability.

Regulation (dysregulated) of BRUNOL4 in neuronal associated with neuronal excitability

2) Confidence 0.39 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.26 Pain Relevance 0.23

Expression analysis of the neighboring genes with potential brain function did not reveal difference between Ff/Ff homozygous mutants and normal controls (unpublished data), suggesting that Brunol4 is the only brain-expressed gene affected by the transgene insertion.

Regulation (affected) of Brunol4 in brain

3) Confidence 0.27 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.09 Pain Relevance 0

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