INT211033

Context Info Confidence 0.37 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.64 Pain Relevance 0.15

mRNA binding (Celf4) mRNA processing (Celf4) RNA binding (Celf4) nucleus (Celf4) cytoplasm (Celf4)

Anatomy Link Frequency brain 1 Celf4 (Mus musculus)

Pain Link Frequency Relevance Heat fluoxetine 6 80.16 Serotonin 9 78.12 cerebral cortex 6 53.20 Hippocampus 30 40.64 Pyramidal cell 9 5.00 Analgesic 3 5.00 Neurotransmitter 3 5.00 Neuronal excitability 3 5.00

Disease Link Frequency Relevance Heat Epilepsy 63 99.24 Absence Epilepsy 15 98.64 Inborn Genetic Diseases 3 97.52 Disease 15 95.64 Convulsion 159 95.36 Sprains And Strains 27 92.28 Targeted Disruption 21 88.88 Weight Gain 6 32.36 Attention Deficit Hyperactivity Disorder 6 31.24 Obesity 3 22.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The prospect of a defective RNA-binding protein such as BRUNOL4 causing a complex seizure disorder suggests a way in which a single gene defect can mimic a complex genetic disease, by impairing the function of multiple molecules simultaneously.

BRUNOL4 Binding (binding) of associated with epilepsy, inborn genetic diseases and disease

1) Confidence 0.37 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.99 Pain Relevance 0

Here, we report on the causal association between Brunol4, encoding a brain-specific RNA-binding protein, and the seizure disorder of frequent-flyer mouse mutants.

Brunol4 Binding (association) of in brain associated with epilepsy

2) Confidence 0.36 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.66 Pain Relevance 0.12

to the insertion site and p2 containing the region between BRUNOL4?

BRUNOL4 Binding (region) of

3) Confidence 0.32 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0 Pain Relevance 0.03

General Comments

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