INT211078

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.53
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
cardiomyocytes 2
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 18 66.32 Quite High
Pain 3 40.60 Quite Low
antagonist 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
b2 receptor 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
substance P 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 15 98.24 Very High Very High Very High
Hypercalcemia 69 97.68 Very High Very High Very High
Chronic Renal Failure 65 96.60 Very High Very High Very High
Hyperplasia 5 84.80 Quite High
Pressure And Volume Under Development 31 81.60 Quite High
Anaemia 1 77.92 Quite High
Cardiomyopathy 28 73.40 Quite High
Uremia 47 71.76 Quite High
Cardiovascular Disorder Under Development 19 66.96 Quite High
Stress 6 49.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like calcitriol, paricalcitol suppresses pre-pro-PTH mRNA synthesis and has a prolonged effect of PTH inhibition beyond its mean half-life of approximately 14 hours in hemodialysis patients (Cato et al 1998; Brandi et al 2002; Staniforth et al 2005).
Negative_regulation (suppresses) of Transcription (synthesis) of PTH
1) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.22 Pain Relevance 0
Under normal conditions, calcitriol regulates the expression of PTH by suppressing transcription of pre-pro-PTH messenger RNA (Russell et al 1986; Silver et al 1986).
Negative_regulation (suppressing) of Transcription (transcription) of PTH
2) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.49 Pain Relevance 0
This was followed in the 1990s by in vitro experiments that demonstrated; an increased cytosolic calcium concentration in isolated rat myocytes in response to PTH [53], a reduced expression of PTH-related peptide receptor mRNA in rat hearts secondary to hyperparathyroidism due to chronic renal failure [54], and increased force and frequency of contraction of isolated, beating rat cardiomyocytes [51, 55].
Negative_regulation (reduced) of Transcription (expression) of PTH in cardiomyocytes associated with chronic renal failure and hypercalcemia
3) Confidence 0.20 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024648 Disease Relevance 0.81 Pain Relevance 0.03

General Comments

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