INT211129

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (P4HB, TNF) plasma membrane (P4HB, TNF) isomerase activity (P4HB)
small molecule metabolic process (P4HB) endoplasmic reticulum (P4HB) intracellular (TNF)
P4HB (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 129 99.30 Very High Very High Very High
spinal inflammation 21 96.68 Very High Very High Very High
cytokine 3 94.96 High High
Inflammation 7 79.60 Quite High
Arthritis 26 78.36 Quite High
rheumatoid arthritis 56 75.92 Quite High
methotrexate 50 59.44 Quite High
metalloproteinase 7 41.44 Quite Low
Etanercept 7 9.92 Low Low
Infliximab 6 7.80 Low Low
Disease Link Frequency Relevance Heat
Low Back Pain 25 96.68 Very High Very High Very High
INFLAMMATION 8 79.60 Quite High
Seronegative Spondarthritis 21 78.36 Quite High
Arthritis 8 77.52 Quite High
Rheumatoid Arthritis 57 75.92 Quite High
Osteoporosis 1 63.12 Quite High
Hypersensitivity 1 61.20 Quite High
Disease 26 26.92 Quite Low
Apoptosis 1 26.40 Quite Low
Infection 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adalimumab exerts its therapeutic effects by blocking the interaction of TNF with the p55 and p75 cell surface TNF receptors.
Negative_regulation (blocking) of p55 Binding (interaction) of TNF associated with adalimumab
1) Confidence 0.10 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936294 Disease Relevance 0.97 Pain Relevance 0.90

General Comments

This test has worked.

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