INT211297

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 1.56
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tails 1
thymus 1
T cells 1
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 57 94.92 High High
Inflammation 206 74.96 Quite High
cytokine 308 68.24 Quite High
Inflammatory response 33 65.04 Quite High
Rheumatism 4 58.68 Quite High
Infliximab 4 40.56 Quite Low
withdrawal 29 5.00 Very Low Very Low Very Low
Spontaneous pain 25 5.00 Very Low Very Low Very Low
Arthritis 21 5.00 Very Low Very Low Very Low
Pain 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 57 94.92 High High
Diabetes Mellitus 9 93.72 High High
Autoimmune Disease 13 92.96 High High
Cancer 4 89.80 High High
Disease 57 75.48 Quite High
INFLAMMATION 239 74.96 Quite High
Apoptosis 4 71.68 Quite High
Rheumatic Diseases 4 58.68 Quite High
Leukemia 9 56.76 Quite High
Targeted Disruption 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As already mentioned, PTPMEG is able to dephosphorylate the TCR ITAMs and to regulate NF-?
Phosphorylation (dephosphorylate) of TCR
1) Confidence 0.27 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.07 Pain Relevance 0.03
Indeed, biochemical approaches and substrate trapping experiments identify PTPH1, together with SHP-1, as the phosphatases able to interact and to dephosphorylate TCR?
Phosphorylation (dephosphorylate) of TCR
2) Confidence 0.27 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0 Pain Relevance 0
Another PTP involved in the immune processes is PTPMEG, a cytosolic phosphatase expressed in the thymus that is able to dephosphorylates TCR?
Phosphorylation (dephosphorylates) of TCR in thymus
3) Confidence 0.27 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.41 Pain Relevance 0.12
The indirect effect of PTPH1 could be mediated by the dephosphorylation of one or several signaling components upstream of Mek and Jnk, such as the TCR-associated protein tyrosine kinases (PTK) or their immediate targets.
Phosphorylation (dephosphorylation) of TCR
4) Confidence 0.27 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.20 Pain Relevance 0.03
In contrast, the majority of TCR?
Phosphorylation (majority) of TCR
5) Confidence 0.21 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.07 Pain Relevance 0
PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [13].
Phosphorylation (phosphorylation) of TCR in T cells
6) Confidence 0.21 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.22 Pain Relevance 0.04
Both antibodies recognize phosphorylated as well as unphosphorylated forms of the TCR?
Phosphorylation (phosphorylated) of TCR
7) Confidence 0.16 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.22 Pain Relevance 0.03
Both antibodies recognize phosphorylated as well as unphosphorylated forms of the TCR?
Phosphorylation (unphosphorylated) of TCR
8) Confidence 0.16 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.22 Pain Relevance 0.03
homodimers and transmit signals inside the cell following TCR ligation-induced tyrosine phosphorylation of immune receptor tyrosine-based activation motifs contained within their extended intracytoplasmic tails.3–5 These phosphotyrosine motifs form docking sites for Syk family tyrosine kinases, such as ?
Phosphorylation (phosphorylation) of TCR in tails
9) Confidence 0.16 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.15 Pain Relevance 0.04

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