INT211376

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.30
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TYMP) cytosol (TYMP) small molecule metabolic process (TYMP)
Anatomy Link Frequency
white blood cells 2
blood cells 2
TYMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 8 74.08 Quite High
palliative 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
chest pain 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 4 100.00 Very High Very High Very High
Cancer 51 99.68 Very High Very High Very High
Malignant Neoplastic Disease 6 99.08 Very High Very High Very High
Death 2 84.84 Quite High
Advanced Or Metastatic Breast Cancer 18 77.04 Quite High
Neuroendocrine Cancer 6 70.12 Quite High
Toxicity 29 67.80 Quite High
Disease Progression 4 62.24 Quite High
Thrombocytopenia 8 37.52 Quite Low
Disease 7 27.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Beside a known elevated expression of thymidine phosphorylase within tumour cells and white blood cells [3], paclitaxel and other agents have the ability to induce this enzyme in the mouse model [4].
Positive_regulation (elevated) of Gene_expression (expression) of thymidine phosphorylase in white blood cells associated with cancer
1) Confidence 0.67 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.55 Pain Relevance 0
Moreover, TP expression is induced by radiation [11], which can again result in higher concentrations of 5-FU in irradiated cells.
Positive_regulation (induced) of Gene_expression (expression) of TP
2) Confidence 0.49 Published 2008 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2668587 Disease Relevance 0.48 Pain Relevance 0.07
Expression of thymidine phosphorylase in peripheral blood cells of breast cancer patients is not increased by paclitaxel

Background

Neg (not) Positive_regulation (increased) of Gene_expression (Expression) of thymidine phosphorylase in blood cells associated with breast cancer
3) Confidence 0.45 Published 2007 Journal BMC Clin Pharmacol Section Title Doc Link PMC1939983 Disease Relevance 0.27 Pain Relevance 0

General Comments

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