INT211532

From wiki-pain
Revision as of 01:49, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.52
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) plasma membrane (Ldlr)
lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
bile 2
Ldlr (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 9 99.84 Very High Very High Very High
agonist 30 8.80 Low Low
alcohol 22 5.00 Very Low Very Low Very Low
Inflammation 19 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertriglyceridemia 12 99.60 Very High Very High Very High
Disorder Of Lipid Metabolism 613 98.80 Very High Very High Very High
Metabolic Syndrome 10 98.56 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

18 98.04 Very High Very High Very High
Diabetes Mellitus 16 96.88 Very High Very High Very High
Lipodystrophy 2 95.40 Very High Very High Very High
Obesity 8 93.52 High High
Coronary Heart Disease 72 87.76 High High
Atherosclerosis 106 82.24 Quite High
Hypertension 3 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To decipher the molecular basis of Kit-dependent steatosis, we determined the expression profiles of key genes involved in lipid hepatic metabolism: such as apoliproteins (Apoa1, ApoB), lipoprotein receptors (LdlR, VldlR, Scarb1, Lrp1), lipase (Lipc, LipH, Lpl) and others implicated in hepatic lipidogenesis (Scap, Srebf1, Srebf2), lipid secretion (Pltp, Mttp, Abca1), bile acid synthesis (Cyp8b1, Cyp7a1), lipid transport (Slc10a1, Abcb11, Abcb1a, Abcc2) and a lipodystrophy gene, Lipin 1 (Lpin1), encoding a phosphatidate phosphatase enzyme with transcription activity [26-28].
Localization (secretion) of LdlR in bile associated with bile and lipodystrophy
1) Confidence 0.56 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.16 Pain Relevance 0.05
Newly acquired CE in VLDL and LDL-C is then taken up by the hepatic LDLr for excretion as bile (Morton and Greene 1997).
Localization (excretion) of LDLr in bile associated with bile
2) Confidence 0.38 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.25 Pain Relevance 0.05
Furthermore, CETP activity may be anti-atherogenic if CE-laden lipoproteins are bound by the LDLr for hepatic uptake and excretion.
Localization (excretion) of LDLr
3) Confidence 0.38 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.02 Pain Relevance 0.03
Introduction

‘Multiple dyslipidemia’ is a collective term for the low HDL-cholesterol, elevated triglycerides (TG), and small, dense LDL-cholesterol that is often found in insulin-resistant patients with abdominal obesity, metabolic syndrome, or type 2 diabetes (Krauss et al 2004).

Localization (found) of LDL-cholesterol associated with hypertriglyceridemia, diabetes mellitus, metabolic syndrome and disorder of lipid metabolism
4) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.75 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox