INT211578

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.38 Pain Relevance 0

nucleus (Dbp, Stip1) DNA binding (Dbp) protein complex (Stip1) cytoplasm (Stip1)

Dbp (Mus musculus) Stip1 (Mus musculus)

Pain Link Frequency Relevance Heat isoflurane 2 5.00 imagery 2 5.00 Bile 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Cancer 2 98.98 Gastrointestinal Stromal Tumor 1 94.44 Intestinal Cancer 1 94.20 Leukemia 1 90.68 Hematological Disease 6 34.88 Immunotherapy Of Cancer 2 30.80 Anaemia 5 5.00 Disorder Of Lipid Metabolism 4 5.00 Sprains And Strains 3 5.00 Hyperlipidemia 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The treatment of the Kit-induced tumors had taken a promising perspective with the use of STI-571 (Imatinib, Gleevec Novartis, Basel, Switzerland), that binds to the ATP-binding site, stabilizing the autoinhibitory structure with an inactive tyrosine kinase domain [14].

ATP-binding site Binding (binds) of STI-571 associated with cancer

1) Confidence 0.00 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.38 Pain Relevance 0

General Comments

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