INT211873

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.44
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (TP53, CD40) enzyme binding (TP53, CD40) cell differentiation (TP53)
nucleoplasm (TP53) mitochondrion (TP53) DNA binding (TP53)
TP53 (Homo sapiens)
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 27 55.96 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 99.76 Very High Very High Very High
Hypoxia 40 81.20 Quite High
Stress 1 76.28 Quite High
Carcinoma 1 62.80 Quite High
Metastasis 10 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low
Genomic Instability 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor cells use the tumor suppressor p53, which is usually modified by mutations to debilitate cell cycle controls, to activate hexokinase gene transcription in particular the Type II isoform.
p53 Positive_regulation (activate) of Transcription (transcription) of Type II isoform associated with cancer
1) Confidence 0.03 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1948005 Disease Relevance 1.44 Pain Relevance 0.03

General Comments

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