INT211907

Context Info Confidence 0.13 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 6 Disease Relevance 3.96 Pain Relevance 0.75

chromosome segregation (RIOK3) kinase activity (RIOK3)

RIOK3 (Homo sapiens)

Pain Link Frequency Relevance Heat withdrawal 14 94.44 Buprenorphine 36 94.00 opiate 42 80.68 alcohol 12 80.24 addiction 94 74.92 cannabis 16 5.00 agonist 14 5.00 methadone 12 5.00 depression 6 5.00 antidepressant 4 5.00

Disease Link Frequency Relevance Heat Drug Dependence 282 100.00 Diabetes Mellitus 18 98.78 Injury 132 93.92 Epilepsy 20 90.24 Aggression 4 71.16 Amnesia 4 63.60 Opiate Addiction 6 50.00 Bone Fracture 4 25.76 Disease 8 8.88 Aging 42 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There were 220 and 130 patients respectively in the SUD and N-SUD groups.

Gene_expression (groups) of SUD associated with drug dependence

1) Confidence 0.13 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2396610 Disease Relevance 0.38 Pain Relevance 0.28

There were 220 and 130 patients respectively in the SUD and N-SUD groups.

Gene_expression (groups) of N-SUD associated with drug dependence

2) Confidence 0.13 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2396610 Disease Relevance 0.38 Pain Relevance 0.28

There were 7 deaths in car wrecks in the SUD group but none in the N-SUD group (Student's t = 2.24, df = 215, P = 0.0262).

Gene_expression (group) of N-SUD associated with drug dependence

3) Confidence 0.13 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2396610 Disease Relevance 0.86 Pain Relevance 0

These differences did not appear to be related to untoward rates of medical conditions in SUD patients, and the rate of visual impairment, wearing of spectacles, diabetes and insulin use were found either not to be elevated in the SUD group, or the differences suggested the SUD group enjoyed better health.

Gene_expression (group) of SUD associated with drug dependence and diabetes mellitus

4) Confidence 0.13 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2396610 Disease Relevance 1.13 Pain Relevance 0.12

An approximate F statistic approached significance (P = 0.07), indicating weak evidence in favour of a different relationship between age and both HSC and EPC for the SUD and N-SUD groups – with the SUD group having lower numbers of both HSC's and EPC's compared with NA group members of equivalent age.

Gene_expression (groups) of SUD associated with drug dependence

5) Confidence 0.11 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC1949819 Disease Relevance 0.60 Pain Relevance 0.04

An approximate F statistic approached significance (P = 0.07), indicating weak evidence in favour of a different relationship between age and both HSC and EPC for the SUD and N-SUD groups – with the SUD group having lower numbers of both HSC's and EPC's compared with NA group members of equivalent age.

Gene_expression (groups) of SUD associated with drug dependence

6) Confidence 0.11 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC1949819 Disease Relevance 0.60 Pain Relevance 0.04

General Comments

This test has worked.