INT211918

Context Info Confidence 0.47 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 10 Disease Relevance 0.94 Pain Relevance 0.38

endosome (Tfrc) peptidase activity (Tfrc) mitochondrion (Tfrc) extracellular region (Tfrc) cytoplasmic membrane-bounded vesicle (Tfrc) plasma membrane (Tfrc)

Anatomy Link Frequency T cell 2 capillary 1 vesicle 1 bands 1 Tfrc (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 88 93.52 Inflammation 81 66.88 Pain 6 39.36 cytokine 26 9.36 imagery 21 5.00 Crohn's disease 5 5.00 depression 4 5.00 anesthesia 4 5.00 opiate 4 5.00 Hippocampus 4 5.00

Disease Link Frequency Relevance Heat Infection 29 99.08 Mixed Connective Tissue Disorder 28 94.16 Viral Infection 8 92.52 Iron Overload 4 68.24 INFLAMMATION 79 66.88 Hypoxia 8 50.56 Colitis 21 50.00 Pain 6 39.36 Fatigue 6 39.04 Superinfection 2 29.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

If the choroid plexus acted as a site of brain iron uptake, Tf released by the blood would bind to TfR on the membrane nearest to the capillary, and iron would cross to the membrane that faces the CSF, and be exported by FPN, aided by a ferroxidase such as ceruloplasmin or hephaestin.

TfR Binding (bind) of in capillary

1) Confidence 0.47 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0 Pain Relevance 0.03

Upon binding the TfR, the Tf-TfR complex usually internalizes to endosome, where iron is released from Tf, reduced from the ferric (Fe3+) to the ferrous (Fe2+) form, exported to cytosol by DMT1, and then exported out of the cell by FPN, with the aid of ferroxidases such as ceruloplasmin and hephaestin.

TfR Binding (binding) of

2) Confidence 0.47 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0 Pain Relevance 0.16

Upon binding, the Tf-TfR complex internalizes to a vesicle, iron is released from Tf, reduced to the transportable ferrous form (Fe2+) by a vesicular reductase, Steap3 (Ohgami et al. 2006) and transported across the endosomal membrane into cytosol by DMT1 found in the vesicular membrane.

TfR Binding (internalizes) of in vesicle

3) Confidence 0.36 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0.19 Pain Relevance 0.03

Upon binding the TfR, the Tf-TfR complex usually internalizes to endosome, where iron is released from Tf, reduced from the ferric (Fe3+) to the ferrous (Fe2+) form, exported to cytosol by DMT1, and then exported out of the cell by FPN, with the aid of ferroxidases such as ceruloplasmin and hephaestin.

TfR Binding (binding) of

4) Confidence 0.35 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0 Pain Relevance 0.16

Likewise, CD69, CD71, as markers for T cell activation, as well as CD152 (CTLA-4) were found to be expressed only at low levels, and with no difference between patients and controls.

CD71 Binding (markers) of in T cell

5) Confidence 0.16 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.37 Pain Relevance 0

Likewise, CD69, CD71, as markers for T cell activation, as well as CD152 (CTLA-4) were found to be expressed only at low levels, and with no difference between patients and controls.

CD71 Binding (found) of in T cell

6) Confidence 0.16 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.37 Pain Relevance 0

TR, JJG, LGBH, CH and CF carried out the molecular genetic studies and participated in experiments.

TR Binding (participated) of

7) Confidence 0.07 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0 Pain Relevance 0

For example, the TR-LBD undergoes a conformational change upon ligand binding which is necessary for binding of the LBD with LxxLL modules of coactivators [Aranda and Pascual, 2001].

TR-LBD Binding (binding) of

8) Confidence 0.07 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

These protein bands were not observed with similar protein samples immunoprecipitated with control mouse IgG (data not shown) or with antibodies against CD71, the transferin receptor (Figure 2E,F).

CD71 Binding (immunoprecipitated) of in bands

9) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0

The solubilization of non-raft proteins in these samples was complete, as the transferrin receptor (which does not associate with lipid rafts and thus served as a marker of Triton X-100-soluble membranes) was not detected in any of these samples (data not shown).

transferrin receptor Neg (not) Binding (associate) of

10) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0

General Comments

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