INT211949

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.83
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox9) signal transduction (Sox9) nucleus (Sox9)
extracellular matrix organization (Sox9) protein complex assembly (Sox9) DNA binding (Sox9)
Sox9 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 12 71.84 Quite High
Kinase C 4 52.68 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 97.68 Very High Very High Very High
Osteoporosis 136 81.20 Quite High
Fracture Healing 144 77.36 Quite High
Repression 4 70.60 Quite High
Tibia Fractures 12 55.76 Quite High
Injury 24 5.00 Very Low Very Low Very Low
Calcification 4 5.00 Very Low Very Low Very Low
Bone Fracture 4 5.00 Very Low Very Low Very Low
Familial Adenomatous Polyposis 4 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also observed a significant down-regulation of SOX9 and RUNX2 in both of these mice (Figure 2L and 2M).
Negative_regulation (down-regulation) of SOX9
1) Confidence 0.31 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.29 Pain Relevance 0
SOX9 was also down-regulated after treatment of Ad-DKK1, suggesting an inhibition of chondrogenic differentiation after blocking of WNT/?
Negative_regulation (regulated) of SOX9
2) Confidence 0.31 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.06 Pain Relevance 0.06
However, SOX9 was down-regulated in ?
Negative_regulation (down-regulated) of SOX9
3) Confidence 0.31 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.41 Pain Relevance 0
SOX9 was also down-regulated after treatment of Ad-DKK1, suggesting an inhibition of chondrogenic differentiation after blocking of WNT/?
Negative_regulation (down) of SOX9
4) Confidence 0.31 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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