INT211984

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 9.55
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
liver 2
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 270 98.72 Very High Very High Very High
aspirin 11 97.92 Very High Very High Very High
agonist 93 94.92 High High
Central nervous system 19 89.28 High High
Inflammatory mediators 8 88.52 High High
cINOD 43 87.32 High High
cytokine 60 87.08 High High
addiction 3 86.12 High High
Inflammatory stimuli 5 73.04 Quite High
Inflammatory response 34 70.80 Quite High
Disease Link Frequency Relevance Heat
Obesity 313 100.00 Very High Very High Very High
Shock 152 100.00 Very High Very High Very High
Apoptosis 74 99.82 Very High Very High Very High
INFLAMMATION 324 98.72 Very High Very High Very High
Breast Cancer 9 96.56 Very High Very High Very High
Colitis 19 96.24 Very High Very High Very High
Body Weight 151 95.80 Very High Very High Very High
Injury 40 95.20 Very High Very High Very High
Disorder Of Lipid Metabolism 43 94.24 High High
Diabetes Mellitus 41 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
interacts with corepressors NCoR and SMRT, but the importance of this interaction for PPAR?
Regulation (importance) of PPAR Binding (interaction) of
1) Confidence 0.45 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.05 Pain Relevance 0
Several other studies have also demonstrated a similar, important role for PPAR?
Regulation (important) of PPAR Binding (role) of
2) Confidence 0.45 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 1.11 Pain Relevance 0.27
-oxidation with sexual dimorphism, but fenofibrate-regulated obesity is not directly associated with PPAR?
Regulation (regulated) of PPAR Binding (associated) of associated with obesity
3) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.52 Pain Relevance 0
in the liver increased mRNA levels of ACOX, the first and rate-limiting enzyme of PPAR?
Regulation (limiting) of PPAR Binding (enzyme) of in liver
4) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.84 Pain Relevance 0
This comparison reveals that although some genes were altered by HS independent of both PPAR?
Regulation (altered) of PPAR Binding (independent) of associated with shock
5) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.95 Pain Relevance 0.04
the classical transcriptional effects, retinoids and PPAR ligands can act via
Regulation (act) of PPAR Binding (ligands) of
6) Confidence 0.41 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.63 Pain Relevance 0.27
Previously, we found that expression of COX-2, an inducible key enzyme for prostaglandin synthesis, was regulated by 15d-PGJ2, a natural ligand for PPAR?
Regulation (regulated) of PPAR Binding (ligand) of
7) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.24 Pain Relevance 0
PPAR ligand affects spermatogenesis and
Regulation (affects) of PPAR Binding (ligand) of
8) Confidence 0.40 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266973 Disease Relevance 0.09 Pain Relevance 0
induces apoptosis did not affect the DNA binding of PPAR?
Neg (not) Regulation (affect) of PPAR Binding (binding) of associated with apoptosis
9) Confidence 0.40 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 0.83 Pain Relevance 0.55
and presents an essential question: how may PPAR ligands modulate the overexpression of IFN-?
Spec (may) Regulation (modulate) of PPAR Binding (ligands) of
10) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.72 Pain Relevance 0.26
Ms take advantage of both the large ligand-binding domain of PPAR?
Regulation (advantage) of PPAR Binding (domain) of
11) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 0.80 Pain Relevance 0.14
is independent of the promoter context but appears to depend on a physical interaction between PPAR?
Spec (appears) Regulation (depend) of PPAR Binding (interaction) of
12) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.92 Pain Relevance 0.34
To study the effect of the PPAR ligands on cell growth, protein
Regulation (effect) of PPAR Binding (ligands) of
13) Confidence 0.20 Published 2009 Journal PPAR Research Section Body Doc Link PMC2651001 Disease Relevance 0 Pain Relevance 0
MAPK-mediated S84/S114 phosphorylation alters the activity of PPAR?
Regulation (alters) of PPAR Binding (activity) of
14) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.84 Pain Relevance 0

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