INT212135

Context Info Confidence 0.73 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.35 Pain Relevance 0.13

transport (Slc4a3) plasma membrane (Slc4a3)

Slc4a3 (Mus musculus)

Pain Link Frequency Relevance Heat depression 3 92.96 Calcium channel 2 79.92 Inflammation 4 5.00 Central nervous system 3 5.00 palliative 2 5.00 ketamine 2 5.00 anesthesia 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Depression 3 92.96 Night Blindness 1 66.96 Osteogenic Sarcomas 2 53.92 Carcinoma 6 50.68 Blindness 4 50.00 Severe Combined Immunodeficiency 4 47.32 Apoptosis 6 18.80 Nicotine Addiction 2 5.92 Cancer 190 5.00 Metastasis 60 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

E12 (M0630, 1:100, 1 hr; Dako, Mississauga, ON), mouse monoclonal Vimentin (Vim3B4, 1:200, 1 hr; American Research Products, Belmont, MA), mouse monoclonal E-cadherin (36B5, 1:100, overnight; Vector Labs, Burlington, ON), mouse monoclonal p63(7JUL, 1:50, 2 hrs; Vector Labs) and human cytokeratin cocktail (AE1/AE3, 1:200, 1 hr; Dako).

Localization (monoclonal) of AE3

1) Confidence 0.73 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.10 Pain Relevance 0

E12 (M0630, 1:100, 1 hr; Dako, Mississauga, ON), mouse monoclonal Vimentin (Vim3B4, 1:200, 1 hr; American Research Products, Belmont, MA), mouse monoclonal E-cadherin (36B5, 1:100, overnight; Vector Labs, Burlington, ON), mouse monoclonal p63(7JUL, 1:50, 2 hrs; Vector Labs) and human cytokeratin cocktail (AE1/AE3, 1:200, 1 hr; Dako).

Localization (1:200) of AE3

2) Confidence 0.73 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0 Pain Relevance 0

secretion by AE3.

Localization (secretion) of AE3

3) Confidence 0.71 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.25 Pain Relevance 0.13

General Comments

This test has worked.