INT212409

Context Info Confidence 0.02 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 6 Disease Relevance 0.39 Pain Relevance 0

plasma membrane (Efna1, Epha1) extracellular region (Efna1) cell adhesion (Epha1) kinase activity (Epha1)

Anatomy Link Frequency eye 2 patterning 2 Efna1 (Mus musculus) Epha1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 6 49.60 tetrodotoxin 90 5.00 Thalamus 24 5.00 sodium channel 6 5.00 imagery 6 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 6 83.76 Hypopigmentation 6 58.40 Adhesions 24 54.44 Targeted Disruption 288 5.00 Congenital Anomalies 12 5.00 Sprains And Strains 6 5.00 Overdose 6 5.00 Embryonic Lethality 6 5.00 Vibrio Infection 6 5.00 Strabismus 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, as the targeting of contralateral axons is not appreciably altered, and this is known to be affected by EphA–ephrinA interactions [14,18], it is possible that other or additional mechanisms are involved in targeting of eye-specific projections.

ephrinA Binding (interactions) of EphA in eye

1) Confidence 0.02 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0 Pain Relevance 0

Because repulsive EphA–ephrinA interactions are reported to confine ipsilateral axons to dorsomedial dLGN [13], the ventrolateral expansion of the ipsilateral terminal region is suggestive of changes in EphA–ephrinA expression.

ephrinA Binding (interactions) of EphA

2) Confidence 0.02 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.05 Pain Relevance 0

However, EphA–ephrinA interactions also play a major role in the establishment of topography of contralateral visual projections to central targets [14–18], which complicates the interpretation that these molecules have a role in eye-specific patterning.

ephrinA Binding (interactions) of EphA in patterning

3) Confidence 0.02 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.14 Pain Relevance 0

Because repulsive EphA–ephrinA interactions are reported to confine ipsilateral axons to dorsomedial dLGN [13], the ventrolateral expansion of the ipsilateral terminal region is suggestive of changes in EphA–ephrinA expression.

ephrinA Binding (interactions) of EphA

4) Confidence 0.02 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.05 Pain Relevance 0

However, as the targeting of contralateral axons is not appreciably altered, and this is known to be affected by EphA–ephrinA interactions [14,18], it is possible that other or additional mechanisms are involved in targeting of eye-specific projections.

ephrinA Binding (interactions) of EphA in eye

5) Confidence 0.02 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0 Pain Relevance 0

However, EphA–ephrinA interactions also play a major role in the establishment of topography of contralateral visual projections to central targets [14–18], which complicates the interpretation that these molecules have a role in eye-specific patterning.

ephrinA Binding (interactions) of EphA in patterning

6) Confidence 0.02 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.14 Pain Relevance 0

General Comments

This test has worked.