INT21269

Context Info Confidence 0.50 First Reported 1980 Last Reported 2009 Negated 2 Speculated 0 Reported most in Abstract Documents 14 Total Number 14 Disease Relevance 5.41 Pain Relevance 2.80

extracellular region (Sct)

Anatomy Link Frequency poly 2 duodenum 2 autonomic 2 RGC 2 Sct (Rattus norvegicus)

Pain Link Frequency Relevance Heat lidocaine 7 99.98 Chronic pancreatitis 26 99.28 tetrodotoxin 6 97.36 local anesthetic 2 85.28 vagus nerve 1 80.40 Cholecystokinin 1 67.20 Bile 1 66.56 amygdala 3 56.96 fibrosis 3 50.00 imagery 2 50.00

Disease Link Frequency Relevance Heat Hepatic Veno-occlusive Disease 30 100.00 Pancreatitis 26 99.28 Steatorrhea 3 97.36 Infection 9 95.08 Mucositis 4 93.72 Death 6 91.12 Leukemia 10 88.36 Cystic Fibrosis 3 86.48 Sprains And Strains 18 86.00 Ganglion Cysts 3 85.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mucoadhesion of poly(N-isopropylacrylamide) nanoparticles, which most strongly enhanced sCT absorption, was stronger than that of ionic nanoparticles, and poly(N-vinylacetamide) nanoparticles probably did not adhere to the GI mucosa.

Positive_regulation (enhanced) of Gene_expression (absorption) of sCT in poly

1) Confidence 0.50 Published 1999 Journal Int J Pharm Section Abstract Doc Link 10205611 Disease Relevance 0 Pain Relevance 0

I.v. injection of secretin activates neurons in brain areas controlling autonomic function and emotion.

Positive_regulation (injection) of Gene_expression (injection) of secretin in autonomic

2) Confidence 0.46 Published 2004 Journal Neuroscience Section Abstract Doc Link 15450360 Disease Relevance 0 Pain Relevance 0.10

Percentage increase in ADC after secretin injection and time to peak ADC did not vary among groups.

Positive_regulation (increase) of Gene_expression (injection) of secretin

3) Confidence 0.40 Published 2009 Journal Radiology Section Body Doc Link 19001148 Disease Relevance 0 Pain Relevance 0

The integrated immunoreactive trypsin response to secretin injection in patients with mild to moderate insufficiency was significantly higher compared to controls and to patients with severe insufficiency.

Positive_regulation (response) of Gene_expression (injection) of secretin

4) Confidence 0.35 Published 1984 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6702805 Disease Relevance 0.43 Pain Relevance 0.33

Serum immunoreactive trypsin response to secretin injection in patients with chronic pancreatitis.

Positive_regulation (response) of Gene_expression (injection) of secretin associated with chronic pancreatitis

5) Confidence 0.35 Published 1984 Journal Am. J. Gastroenterol. Section Title Doc Link 6702805 Disease Relevance 0.42 Pain Relevance 0.34

Serum immunoreactive trypsin response to secretin injection (75 clinical units iv over a 2-min period) was studied in patients with chronic pancreatitis and in control subjects.

Positive_regulation (response) of Gene_expression (injection) of secretin associated with chronic pancreatitis

6) Confidence 0.35 Published 1984 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6702805 Disease Relevance 0.32 Pain Relevance 0.25

[Effects of lidocaine upon CCK-PZ and secretin producing paraneurons in the canine duodenum responding to luminal chemical stimuli (author's transl)].

Positive_regulation (upon) of Gene_expression (producing) of secretin in duodenum associated with lidocaine

7) Confidence 0.35 Published 1982 Journal No To Shinkei Section Title Doc Link 7093074 Disease Relevance 0.06 Pain Relevance 0.60

Serum immunoreactive trypsin (IRT) response to secretin injection was studied in 13 patients with chronic pancreatitis with different degrees of exocrine dysfunction and in 10 control subjects.

Positive_regulation (response) of Gene_expression (injection) of secretin associated with chronic pancreatitis

8) Confidence 0.31 Published 1980 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6935752 Disease Relevance 0.23 Pain Relevance 0.23

This effect was specific, since the related peptides PHI-27 and secretin produced no significant increase in RGC survival.

Neg (no) Positive_regulation (increase) of Neg (no) Gene_expression (produced) of secretin in RGC

9) Confidence 0.20 Published 1990 Journal Neuron Section Abstract Doc Link 2169272 Disease Relevance 0.41 Pain Relevance 0.52

Continuous intravenous infusion does not bring about changes in the serum levels of the enzymes studied; rapid injection of secretin, however, induces changes in the serum levels of TLI and lipase (but not amylase) which makes it possible to distinguish patients with chronic pancreatitis in its early stages from advanced chronic pancreatitis but is of doubtful value in distinguishing healthy subjects from those suffering with chronic pancreatitis.

Positive_regulation (induces) of Gene_expression (injection) of secretin associated with chronic pancreatitis

10) Confidence 0.11 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 2581746 Disease Relevance 0.44 Pain Relevance 0.44

No cases of SOS occurred in our series, even after SCT in the three responding patients.

Positive_regulation (even) of Gene_expression (occurred) of SCT associated with hepatic veno-occlusive disease

11) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1523361 Disease Relevance 1.31 Pain Relevance 0

No cases of SOS occurred in our series, even after SCT in the three responding patients.

Neg (No) Positive_regulation (cases) of Gene_expression (occurred) of SCT associated with hepatic veno-occlusive disease

12) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1523361 Disease Relevance 1.32 Pain Relevance 0

METHODS: Fifty-six patients under treatment for alcohol dependence were stimulated by intravenous injection of secretin during endoscopic retrograde cholangiopancreatography to provide pancreatic juice specimens.

Positive_regulation (stimulated) of Gene_expression (injection) of secretin

13) Confidence 0.04 Published 2004 Journal Intern. Med. Section Body Doc Link 15645646 Disease Relevance 0.33 Pain Relevance 0

In one, overexpression of the pIV protein (a secretin from the filamentous phage f1) was shown to induce the pspABCDE operon, as well as an additional gene, pspG [48].

Positive_regulation (overexpression) of Gene_expression (overexpression) of secretin

14) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2731931 Disease Relevance 0.15 Pain Relevance 0

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