INT212957

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.89
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
endothelial cells 2
astrocytes 2
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 9 83.20 Quite High
ischemia 5 70.64 Quite High
cva 1 69.60 Quite High
Spinal cord 1 69.12 Quite High
agonist 1 36.48 Quite Low
Inflammation 11 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 3 99.58 Very High Very High Very High
Disorder Of Lipid Metabolism 137 97.28 Very High Very High Very High
Necrosis 4 94.48 High High
Cancer 2 94.12 High High
Hypoxia 1 90.76 High High
Stroke 27 83.72 Quite High
Cv General 4 Under Development 1 71.36 Quite High
Hemorrhage 1 69.60 Quite High
INFLAMMATION 19 50.00 Quite Low
Injury 2 48.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The concomitant MSC induced reduction of PAI-1 and increase of tPA in astrocytes of the IBZ thereby amplify tPA activity which contributes to neurite outgrowth.
Positive_regulation (induced) of Localization (reduction) of PAI in astrocytes
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.72 Pain Relevance 0.15
Hypercholesterolemia and hypertriglyceridemia are associated with increased secretion of PAI-1 from endothelial cells (Stiko-Rahm et al 1990; Norata, Pirillo, et al 2003).
Positive_regulation (increased) of Localization (secretion) of PAI in endothelial cells associated with hyperlipidemia
2) Confidence 0.31 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.17 Pain Relevance 0

General Comments

This test has worked.

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