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Context Info
Confidence 0.28
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
lymphocyte 1
Gnrh1 (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 99.96 Very High Very High Very High
conotoxin 2 99.36 Very High Very High Very High
tetrodotoxin 1 81.60 Quite High
Neuropeptide 1 57.60 Quite High
opiate 1 56.24 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Omega-conotoxin (omega-CgTx, 100 nM) partially suppressed FSH and LH release (NS) due to both K+ (33% each) and GnRH (44% and 18%, respectively). omega-CgTx showed variable effects on [Ca2+]i transients evoked by K+ or GnRH ranging from clear inhibition to no effect.
GnRH Negative_regulation (suppressed) of LH associated with conotoxin
1) Confidence 0.28 Published 1990 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 2170211 Disease Relevance 0 Pain Relevance 0.17
In other studies, this LH response evoked by lymphocyte lysates was found to be dose dependent and could be significantly inhibited by an LHRH-antagonist.
LHRH Negative_regulation (inhibited) of LH in lymphocyte associated with antagonist
2) Confidence 0.21 Published 1990 Journal Endocrinology Section Abstract Doc Link 2184019 Disease Relevance 0 Pain Relevance 0.14

General Comments

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