INT2132

Context Info Confidence 0.81 First Reported 1978 Last Reported 2011 Negated 1 Speculated 0 Reported most in Abstract Documents 29 Total Number 29 Disease Relevance 8.39 Pain Relevance 5.43

extracellular region (SCT) cellular_component (SCT)

Anatomy Link Frequency plasma 3 duodenum 2 pituitary 2 acinar cells 1 stem cell 1 SCT (Homo sapiens)

Pain Link Frequency Relevance Heat Cholecystokinin 26 100.00 Serotonin 7 100.00 substance P 1 100.00 Glutamate 16 99.96 Bile 7 99.82 narcan 9 99.70 Enkephalin 2 99.50 dexamethasone 1155 99.32 Dopamine 6 99.06 alcohol 79 98.00

Disease Link Frequency Relevance Heat Thrombosis 49 100.00 Pituitary Cancer 4 99.96 Adhesions 25 99.54 Thrombocytopenia 60 99.44 Peripheral Arterial Disease 9 99.32 Anaemia 39 98.60 Diarrhoea 23 97.80 Multiple Myeloma 528 97.70 Exocrine Pancreatic Insufficiency 6 96.08 Acid Reflux 4 95.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Otherwise a weak stimulation occurs with release of secretin.

Localization (release) of secretin

1) Confidence 0.81 Published 1978 Journal Leber Magen Darm Section Abstract Doc Link 359968 Disease Relevance 0.08 Pain Relevance 0.29

In man there are diverging results concerning the effect of secretin on gastric secretion.

Localization (secretion) of secretin

2) Confidence 0.77 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2892264 Disease Relevance 0.47 Pain Relevance 0.18

It is known that secretin has a suppressive effect on gastric secretion [30].

Localization (secretion) of secretin

3) Confidence 0.77 Published 2005 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC1308834 Disease Relevance 1.09 Pain Relevance 0.04

Secretin is an important physiologic regulator of gastric acid and pancreatic bicarbonate secretion.

Localization (secretion) of Secretin

4) Confidence 0.75 Published 1995 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7769193 Disease Relevance 0.08 Pain Relevance 0.15

Secretin inhibits gastric secretion of acid and gastrin in dog and a physiological role of secretin as an enterogastrone has been suggested in this species.

Localization (secretion) of secretin

5) Confidence 0.72 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2892264 Disease Relevance 0.26 Pain Relevance 0.14

Pancreatic ductal cells are largely responsible for the amount of bicarbonate and water secretion in response to secretin stimulation.

Localization (secretion) of secretin

6) Confidence 0.71 Published 2005 Journal JOP Section Abstract Doc Link 15767727 Disease Relevance 0.70 Pain Relevance 0.27

Exogenous secretin reduced pentagastrin-stimulated acid secretion by 35%, and this inhibition was reduced to 9% during indomethacin treatment (p < 0.05).

Localization (secretion) of secretin

7) Confidence 0.70 Published 1995 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7769193 Disease Relevance 0.08 Pain Relevance 0.16

When subjects received misoprostol treatment only, secretin failed to inhibit gastric acid secretion.

Localization (secretion) of secretin

8) Confidence 0.70 Published 1995 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7769193 Disease Relevance 0.14 Pain Relevance 0.21

Atropine either moderately depressed or did not alter the volume and bicarbonate response to secretin but constantly reduced enzyme secretion.

Localization (secretion) of secretin

9) Confidence 0.68 Published 1979 Journal Schweiz Med Wochenschr Section Abstract Doc Link 515711 Disease Relevance 0 Pain Relevance 0.09

It would seem that the primary inhibitory effect of the elemental diet may be more specifically related to a reduction of secretin release.

Localization (release) of secretin

10) Confidence 0.68 Published 1980 Journal Surg Gynecol Obstet Section Abstract Doc Link 7404299 Disease Relevance 0.15 Pain Relevance 0.21

Intravenous administration of naloxone (40 micrograms/kg/hr) had no effect on serum gastrin and secretin concentrations or on the gastric acid secretion stimulated by pentagastrin (n = 8).

Localization (secretion) of secretin associated with narcan

11) Confidence 0.56 Published 1993 Journal Hokkaido Igaku Zasshi Section Abstract Doc Link 8112709 Disease Relevance 0 Pain Relevance 0.82

Clear evidence is presented that this feedback mechanism is working in the rat and the pig and that this feedback is mediated in the rat by the gastrointestinal hormones pancreozymin (enzyme secretion) and secretin (volume and bicarbonate secretion).

Localization (secretion) of secretin associated with bile

12) Confidence 0.54 Published 1990 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2124996 Disease Relevance 0 Pain Relevance 0.05

Clear evidence is presented that this feedback mechanism is working in the rat and the pig and that this feedback is mediated in the rat by the gastrointestinal hormones pancreozymin (enzyme secretion) and secretin (volume and bicarbonate secretion).

Localization (secretion) of secretin associated with bile

13) Confidence 0.54 Published 1990 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2124996 Disease Relevance 0 Pain Relevance 0.05

The concentrations of secretin and CCK in plasma and the pancreatic enzyme and volume secretions were unaffected by the addition of trypsin, but the initial bile acid output and the bicarbonate secretion in the period after gallbladder emptying were reduced during perfusion with trypsin.

Localization (secretions) of secretin in plasma associated with bile and cholecystokinin

14) Confidence 0.46 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.18 Pain Relevance 0.29

To study the effects of trypsin on the pancreaticobiliary secretion and the release of secretin and cholecystokinin (CCK) to plasma, seven normal subjects were stimulated twice with duodenal perfusates containing 20 mM oleic acid (pH 6.0) with and without 1 g of bovine trypsin added per liter.

Localization (secretion) of secretin in plasma associated with cholecystokinin

15) Confidence 0.43 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.08 Pain Relevance 0.16

Furthermore, the reduced duodenal output of bicarbonate found in response to trypsin is not explained by changes in the release of secretin or CCK.

Localization (release) of secretin associated with cholecystokinin

16) Confidence 0.43 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.16 Pain Relevance 0.27

To study the effects of trypsin on the pancreaticobiliary secretion and the release of secretin and cholecystokinin (CCK) to plasma, seven normal subjects were stimulated twice with duodenal perfusates containing 20 mM oleic acid (pH 6.0) with and without 1 g of bovine trypsin added per liter.

Localization (release) of secretin in plasma associated with cholecystokinin

17) Confidence 0.43 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.08 Pain Relevance 0.16

The specificity of the VIP effect was tested with peptides structurally related to VIP such as glucagon, secretin, gastric inhibitory polypeptide and human growth-hormone releasing factor.

Localization (releasing) of secretin

18) Confidence 0.40 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2829291 Disease Relevance 0 Pain Relevance 0.09

Gastrin affects pancreatic secretion by two mechanisms: gastric acid secretion, resulting in secretin secretion when a low pH reaches the duodenum and a direct effect of gastrin on acinar cells to produce an enzyme-rich secretion.

Localization (secretion) of secretin in acinar cells

19) Confidence 0.23 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0.13 Pain Relevance 0.11

The chicken GPCR dataset was divided into Adhesion, Frizzled, Glutamate, Secretin, Rhodopsin, and Taste 2 families based on the human dataset.

Localization (based) of Secretin associated with glutamate and adhesions

20) Confidence 0.23 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

This test has worked.