INT21349

Context Info Confidence 0.07 First Reported 1990 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.90 Pain Relevance 0.34

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)

Anatomy Link Frequency neutrophils 2 platelet 1 Ltb4r1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 65 97.68 antagonist 30 80.40 peptic ulcer disease 1 79.88 Inflammatory mediators 1 64.32 fibrosis 3 44.88 cINOD 19 25.52 trigger zone 1 22.68 COX-2 inhibitor 10 11.04 corticosteroid 51 5.00 cytokine 23 5.00

Disease Link Frequency Relevance Heat Ulcers 4 99.36 INFLAMMATION 67 97.68 Pulmonary Disease 107 97.00 Duodenal Ulcer 6 96.92 Leukemia 1 93.60 Colon Cancer 5 92.00 Apoptosis 44 90.28 Asthma 88 85.28 Disease 36 79.88 Cancer 78 76.80

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

LTB4 interacts with the high-affinity BLT1 receptor expressed by immune/inflammatory cells, thus exerting a powerful chemoattractant effect particularly on neutrophils, but also on CD8+ T-cells (Martin et al 1989; Goodarzi et al 2003).

LTB4 Binding (interacts) of in neutrophils associated with inflammation

1) Confidence 0.07 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.93 Pain Relevance 0.23

Evidence also indicates that 15-S-HETE may have anti-tumorigenic effects by antagonizing other LOX products, such as LTB4 and 12-S-HETE [28]. 15-HETE inhibits LTB4 production and reduces LTB4 binding to its receptors and thereby blocks cellular responses to LTB4. 15-HETE also blocks platelet-type 12-LOX activity and reduces 5-LOX activity in rat basophilic leukemia cells [28,32].

LTB4 Binding (binding) of in platelet associated with leukemia

2) Confidence 0.03 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.76 Pain Relevance 0

Fundic LTB4 and LTC4 generation was similar in ulcer patients and controls.

LTB4 Binding (generation) of associated with ulcers

3) Confidence 0.02 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.85 Pain Relevance 0.08

The non-cysteinyl LT, LTB4, binds to the B leukotriene (BLT) receptor, which is responsible for recruitment and activation of leukocytes, in particular neutrophils (Yokomizo et al 1997; Devillier et al 1999a).

LTB4 Binding (binds) of in neutrophils

4) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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