INT213515

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.92
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
sclerotome 1
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 86.96 High High
cytokine 25 20.24 Low Low
bDMF 49 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
imagery 13 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
backache 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 32 95.12 Very High Very High Very High
Corneal Neovascularization 24 92.72 High High
Medulloblastoma 60 89.44 High High
Basal Cell Carcinoma 92 88.60 High High
Basal Cell Nevus Syndrome 176 87.20 High High
Targeted Disruption 2 69.88 Quite High
Burns 26 69.12 Quite High
Bacterial Infection 4 66.16 Quite High
Cancer 94 66.08 Quite High
Pressure And Volume Under Development 9 58.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclopamine indeed counteracted exogenous Shh-induced NV.
Shh Binding (counteracted) of
1) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.24 Pain Relevance 0
Cyclopamine indeed counteracted exogenous Shh-induced NV.
Shh Binding (counteracted) of
2) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.36 Pain Relevance 0
Four treatment groups were prepared: 1) control without exogenous agents; 2) a polymer pellet containing recombinant Shh (50 ?
Shh Binding (recombinant) of
3) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.11 Pain Relevance 0
g/ml in phosphate-buffered saline [PBS]; R&D systems); 3) a polymer pellet with cyclopamine (2.5 mg/ml in PBS, Toronto Reserch Chemicals); and 4) with recombinant Shh (50 ?
Shh Binding (recombinant) of
4) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.12 Pain Relevance 0
Thus, it may be that EGF and Shh interact with one another to regulate papillary number.
Shh Binding (interact) of
5) Confidence 0.31 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.07 Pain Relevance 0.03
Patterning of the somites is regulated by opposing gradients of Shh and Wnt signaling, with Shh being specifically responsible for definition of the sclerotome (Ehlen et al., 2006).
Shh Binding (gradients) of in sclerotome
6) Confidence 0.26 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.11 Pain Relevance 0.04
If a mutation occurs in PTCH1 and the second loop is not formed, SHH cannot bind.
SHH Binding (bind) of
7) Confidence 0.12 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 0.44 Pain Relevance 0
It encodes a transmembrane glycoprotein composed of 1447 amino acids, with 12 transmembrane domains and two large hydrophilic extracellular loops where Sonic Hedgehog (SHH) ligand binding occurs.
SHH Binding (binding) of
8) Confidence 0.12 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 0.46 Pain Relevance 0

General Comments

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