INT213726

Context Info Confidence 0.14 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.96 Pain Relevance 0.72

cell differentiation (Ngfr, Ntrk1) cytoplasm (Ngfr, Ntrk1) plasma membrane (Ngfr, Ntrk1) endosome (Ntrk1) nuclear envelope (Ngfr) aging (Ntrk1)

Anatomy Link Frequency dendrite 1 Ngfr (Rattus norvegicus) Ntrk1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neurotransmitter 1 97.16 Nerve growth factor 79 88.20 interstitial cystitis 12 81.16 Pain 7 79.00 Inflammation 7 75.72 hyperexcitability 2 70.56 intrathecal 6 63.68 Spinal cord 43 55.28 Calcitonin gene-related peptide 33 50.40 Dorsal horn 23 5.00

Disease Link Frequency Relevance Heat Cystitis 5 99.40 Overactive Bladder 45 88.76 Urinary Dysfunction 1 83.64 Interstitial Cystitis 12 81.16 Bladder Disease 3 79.68 INFLAMMATION 7 75.72 Hypertension 1 56.00 Nociception 3 36.48 Urological Neuroanatomy 13 5.00 Pain 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Neurotrophin/Trk and/or p75NTR interactions could induce long-term changes in cells [4], including: (1) mediating neurotransmitter phenotype; (2) influencing dendrite size and synaptic reorganization; (3) increasing synaptic efficacy; and (4) controlling innervation density and target organ function.

p75NTR Binding (interactions) of Trk in dendrite associated with neurotransmitter

1) Confidence 0.14 Published 2007 Journal BMC Physiol Section Body Doc Link PMC2000875 Disease Relevance 0.96 Pain Relevance 0.72

General Comments

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