INT213787

Context Info Confidence 0.39 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.55 Pain Relevance 0.27

nucleus (Tfeb) DNA binding (Tfeb) cytoplasm (Tfeb)

Tfeb (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 43 97.64 Inflammatory response 7 5.00 interstitial cystitis 4 5.00 Inflammatory stimuli 3 5.00 substance P 3 5.00 Pain 2 5.00 cytokine 1 5.00 ketamine 1 5.00 Inflammatory mediators 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 54 97.64 Microphthalmia 23 5.00 Overactive Bladder 11 5.00 Cystitis 8 5.00 Interstitial Cystitis 4 5.00 Renal Cancer 3 5.00 Injury 3 5.00 Bladder Cancer 2 5.00 Pain 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

EMSA results confirmed the increased TFEB binding activity in C57BL/6 but not in Kitw/Kitw-v mice.

Positive_regulation (increased) of TFEB Binding (activity) of

1) Confidence 0.39 Published 2007 Journal BMC Immunol Section Abstract Doc Link PMC2000913 Disease Relevance 0.55 Pain Relevance 0.27

General Comments

This test has worked.