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Context Info
Confidence 0.43
First Reported 1976
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 3.37
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cga)
Anatomy Link Frequency
plasma 1
Leydig cells 1
neurons 1
amygdala 1
Cga (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 7 100.00 Very High Very High Very High
Dopamine 6 100.00 Very High Very High Very High
Thalamus 4 100.00 Very High Very High Very High
Hippocampus 1 100.00 Very High Very High Very High
Pain 7 99.16 Very High Very High Very High
lidocaine 2 98.98 Very High Very High Very High
tetrodotoxin 2 98.40 Very High Very High Very High
narcan 11 96.86 Very High Very High Very High
antagonist 2 87.52 High High
Central grey 5 87.28 High High
Disease Link Frequency Relevance Heat
Breast Cancer 1 99.66 Very High Very High Very High
Macromastia 2 99.44 Very High Very High Very High
Cancer 14 99.24 Very High Very High Very High
Pain 3 99.16 Very High Very High Very High
Hypotension 2 97.84 Very High Very High Very High
Appetite Loss 5 96.88 Very High Very High Very High
Pinealoma 4 95.28 Very High Very High Very High
Hemolysis 1 85.68 High High
Urological Neuroanatomy 5 85.36 High High
Headache 1 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bilateral intratesticular injection of increasing doses of naloxone (0.1-10 micrograms/testis) resulted 24 h later in a dose-dependent increase in testosterone production by Leydig cells incubated for 3 h in the presence or absence of hCG (100 ng/ml).
Negative_regulation (absence) of hCG in Leydig cells associated with narcan
1) Confidence 0.43 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485243 Disease Relevance 0 Pain Relevance 0.36
50 patients with primary breast cancer were studied to determine the CEA and HCG contents in their tumor cells before any treatment was initiated.
Spec (determine) Negative_regulation (determine) of HCG associated with cancer and breast cancer
2) Confidence 0.24 Published 1978 Journal Cancer Section Abstract Doc Link 361213 Disease Relevance 0.75 Pain Relevance 0
Similarly, microinjections of cobalt chloride (a neurotransmission blocker) into the anterior portion of the LHA also decrease the arterial pressure responses to IL stimulation, suggesting that the ability of lidocaine to reversibly block the evoked response is due to inactivation of neurons in the LHA.
Negative_regulation (inactivation) of LHA in LHA associated with lidocaine
3) Confidence 0.24 Published 2000 Journal Brain Res. Section Abstract Doc Link 10720617 Disease Relevance 0.49 Pain Relevance 0.49
Combined application of electric pain stimulation and LPS injection results in diminished activation level in AHN, PVH, LHA and VMH as compared with typical response to single LPS injection without EPS.
Negative_regulation (diminished) of LHA associated with pain
4) Confidence 0.12 Published 2006 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 17385422 Disease Relevance 0.57 Pain Relevance 0.27
A partial resection of the tumor and an external X-ray irradiation relieved the symptoms and breast enlargement subsided with a remarkable decrease in the plasma HCG level.
Negative_regulation (decrease) of HCG in plasma associated with macromastia and cancer
5) Confidence 0.08 Published 1976 Journal Endocrinol. Jpn. Section Abstract Doc Link 991833 Disease Relevance 1.09 Pain Relevance 0.08
Sensitivity of LHA neurons to DA was reduced by extinction of CTS+ learning for reward, and sensitivity to ACh was reduced by CTS- learning for aversion.
Negative_regulation (reduced) of LHA in neurons associated with dopamine
6) Confidence 0.02 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2207696 Disease Relevance 0.08 Pain Relevance 0.31
Experiment 1 examined the effects of bilateral reversible inactivation of amygdala (Amy), hippocampus (Hipp), gustatory cortex (GC), bed nucleus of stria terminalis (BNST), lateral hypothalamic area (LHA), ventral thalamus (VT) or LHA+VT, induced by intracerebral injection of tetrodotoxin (TTX; 10 ng/microliters per site) applied before i.p. injection of LiCl to rats anesthetized by pentobarbital (50 mg/kg) immediately after saccharin drinking.
Spec (examined) Negative_regulation (inactivation) of LHA+VT in amygdala associated with tetrodotoxin, thalamus, hippocampus and amygdala
7) Confidence 0.01 Published 1994 Journal Behav. Brain Res. Section Abstract Doc Link 7718154 Disease Relevance 0.40 Pain Relevance 0.59

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