INT213800

Context Info Confidence 0.30 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.24 Pain Relevance 0.15

cell differentiation (Kit, Mitf) pigmentation (Kit, Mitf) nucleus (Kit, Mitf) protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)

Anatomy Link Frequency mast cell 1 Kit (Mus musculus) Mitf (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory response 7 91.68 Inflammation 43 72.32 substance P 3 67.92 agonist 1 42.40 interstitial cystitis 4 5.00 Inflammatory stimuli 3 5.00 Pain 2 5.00 cytokine 1 5.00 ketamine 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Microphthalmia 23 100.00 INFLAMMATION 54 91.68 Leukemia 1 76.64 Renal Cancer 3 71.48 Genetic Translocation 1 63.04 Overactive Bladder 11 5.00 Cystitis 8 5.00 Interstitial Cystitis 4 5.00 Injury 3 5.00 Bladder Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, c-kit- and m-Csf-dependent MAPK phosphorylation transcriptionally activates both TFE3 and MiTF, which is necessary for mast cell developmental functions [54].

c-kit Positive_regulation (activates) of MiTF in mast cell associated with microphthalmia

1) Confidence 0.30 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.24 Pain Relevance 0.15

General Comments

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