INT213967

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Context Info
Confidence 0.30
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.52
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
cornea 2
T-cells 2
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 33 88.00 High High
Sicca syndrome 21 86.00 High High
Inflammatory response 1 80.64 Quite High
Inflammation 46 77.60 Quite High
Neuropeptide 32 75.44 Quite High
Somatostatin 17 50.36 Quite High
substance P 42 37.36 Quite Low
cva 1 5.04 Very Low Very Low Very Low
Calcitonin gene-related peptide 15 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 180 99.76 Very High Very High Very High
Eye Disease 11 96.88 Very High Very High Very High
Adhesions 7 94.20 High High
Necrosis 4 93.44 High High
Disorders Of The Lacrimal System 37 89.88 High High
Death 2 87.36 High High
Hypersensitivity 4 86.84 High High
Syndrome 23 86.00 High High
Shock 5 85.40 High High
Metaplasia 22 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sparse-scan HIFU was more effective than dense-scan HIFU in enhancing infiltration of DCs into tumor tissues and promoting their maturation in situ
Positive_regulation (enhancing) of Localization (infiltration) of DCs associated with cancer
1) Confidence 0.30 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 1.00 Pain Relevance 0
In our investigation of the afferent arm of the immune loop, we observed an accumulation of DCs in the limbus and mobilization of activated DCs into the cornea.
Positive_regulation (accumulation) of Localization (mobilization) of DCs in cornea
2) Confidence 0.18 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.57 Pain Relevance 0.15
By signalling through the VPAC1 receptor, VIP was shown to induce the maturation of immature DCs leading to an enhanced production of IL-12 and an enhanced expression of the DC-maturation marker CD83, especially in the presence of suboptimal amounts of tumour necrosis factor-?
Positive_regulation (through) of Localization (maturation) of DCs associated with necrosis and cancer
3) Confidence 0.11 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.41 Pain Relevance 0.20
Following antigenic stimulation both DCs and T-cells upregulate C3a and C5a receptors, produce C3, alternative complement factors B and D, and downregulate CD55.
Positive_regulation (upregulate) of Localization (stimulation) of DCs in T-cells
4) Confidence 0.04 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.54 Pain Relevance 0.11

General Comments

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