INT2140

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 23
Speculated 7
Reported most in Abstract
Documents 104
Total Number 111
Disease Relevance 28.24
Pain Relevance 24.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 50
blood 12
sympathetic nervous system 3
sinus 2
heart 2
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 77 100.00 Very High Very High Very High
Clonidine 66 100.00 Very High Very High Very High
narcan 37 100.00 Very High Very High Very High
Catecholamine 28 100.00 Very High Very High Very High
bradykinin 21 100.00 Very High Very High Very High
agonist 16 100.00 Very High Very High Very High
beta blocker 11 100.00 Very High Very High Very High
Somatostatin 7 100.00 Very High Very High Very High
ketamine 5 100.00 Very High Very High Very High
transdermal 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 55 100.00 Very High Very High Very High
Natriuresis 48 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 12 100.00 Very High Very High Very High
Affective Disorder 2 99.84 Very High Very High Very High
Insulin Resistance 5 99.50 Very High Very High Very High
Hypertension 181 99.42 Very High Very High Very High
Cerebral Aneurysm 2 99.40 Very High Very High Very High
Pyelonephritis 6 99.34 Very High Very High Very High
Hyperglycemia 3 99.02 Very High Very High Very High
Pressure And Volume Under Development 56 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension.
Regulation (effect) of renin in plasma associated with pressure and volume under development
1) Confidence 0.62 Published 1976 Journal Klin. Wochenschr. Section Title Doc Link 790007 Disease Relevance 0.40 Pain Relevance 0.07
The effect of the new vasodilator, minoxidil, on blood pressure and plasma renin activity was studied in 21 hypertensive patients: 12 patients with essential and 9 with renal hypertension.
Regulation (effect) of renin in plasma associated with pressure and volume under development and hypertension
2) Confidence 0.62 Published 1976 Journal Klin. Wochenschr. Section Abstract Doc Link 790007 Disease Relevance 0.27 Pain Relevance 0.05
Effect of clonidine (Haemiton) on plasma renin level and angiotensin sensitivity in man.
Regulation (sensitivity) of renin in plasma associated with clonidine
3) Confidence 0.62 Published 1978 Journal Int J Clin Pharmacol Biopharm Section Title Doc Link 700917 Disease Relevance 0 Pain Relevance 0.47
The effect of clonidine and of clonidine + spironolactone on renin activity and angiotensin sensitivity has been studied in 15 persons.
Regulation (effect) of renin associated with clonidine
4) Confidence 0.62 Published 1978 Journal Int J Clin Pharmacol Biopharm Section Abstract Doc Link 700917 Disease Relevance 0 Pain Relevance 0.44
The phenomenon is explained by the contrary effects of the two drugs on renin activity and angiotensin sensitivity.
Regulation (effects) of renin
5) Confidence 0.62 Published 1978 Journal Int J Clin Pharmacol Biopharm Section Abstract Doc Link 700917 Disease Relevance 0 Pain Relevance 0.44
These data demonstrate that both the GFR and renin responses to furosemide are altered during ontogeny.
Regulation (altered) of renin
6) Confidence 0.60 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 7600440 Disease Relevance 0.17 Pain Relevance 0.10
There was a dose-related increase in nonesterified fatty acids and a fall in plasma lactate levels but no changes in plasma renin activity or blood glucose.
Neg (no) Regulation (changes) of renin in plasma
7) Confidence 0.60 Published 1984 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 6143634 Disease Relevance 0 Pain Relevance 0.12
To study central and peripheral mechanisms that regulate the level of circulating renin during activation of the carotid sinus baroreflex, both carotid sinuses were isolated and perfused at constant flow in chloralase-anesthetized dogs.
Regulation (regulate) of renin in sinus
8) Confidence 0.59 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7039357 Disease Relevance 0.07 Pain Relevance 0
As the half-life of plasma renin is 15 min, the data suggest that the persistently increased plasma renin activity is probably responsible for the increase of arterial pressure following sodium nitroprusside-induced hypotension.
Regulation (responsible) of plasma renin in plasma associated with hypotension
9) Confidence 0.52 Published 1979 Journal Anesthesiology Section Abstract Doc Link 453612 Disease Relevance 0.55 Pain Relevance 0.24
The effect of pentobarbital anesthesia on plasma renin activity (PRA) and mean arterial pressure (MAP) was studied in chronically catheterized dogs maintained on normal or low-sodium intake.
Regulation (effect) of renin in plasma associated with anesthesia
10) Confidence 0.52 Published 1976 Journal Am. J. Physiol. Section Abstract Doc Link 984205 Disease Relevance 0 Pain Relevance 0.25
These results suggest that the renin and RBF responses to RNS are modulated by concomitantly released PG.
Regulation (modulated) of renin
11) Confidence 0.50 Published 1983 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6342558 Disease Relevance 0 Pain Relevance 0
Studies on the responses of plasma renin activity and aldosterone and cortisol levels to dopaminergic and opiate stimuli in man.
Regulation (responses) of renin in plasma associated with narcan and opiate
12) Confidence 0.45 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 7030527 Disease Relevance 0 Pain Relevance 0.45
Acute effects of prizidilol on blood pressure, heart rate, catecholamines, renin and aldosterone in essential hypertension.
Regulation (effects) of renin in heart associated with catecholamine and hypertension
13) Confidence 0.45 Published 1982 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 6129141 Disease Relevance 0.30 Pain Relevance 0.14
In contrast, during sympathetic blockade and despite identical hypotension (mean arterial blood pressure 68 +/- 8 vs. 67 +/- 5 mmHg), renin concentration did not change (35 +/- 27 vs. 35 +/- 29 pg.ml-1, P = 0.5), whereas vasopressin concentration increased (4.6 +/- 2.5 to 13.4 +/- 9.4 pg.ml-1, P = 0.01).
Neg (not) Regulation (change) of renin in blood
14) Confidence 0.45 Published 1994 Journal Anesthesiology Section Body Doc Link 8017664 Disease Relevance 0 Pain Relevance 0
Effects of a non-vasoconstrictor dose of phenylephrine on prostaglandin E2 and renin release in anaesthetized dogs.
Regulation (Effects) of renin associated with anesthesia
15) Confidence 0.45 Published 1983 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 6347479 Disease Relevance 0 Pain Relevance 0.10
Blood volume and plasma renin concentration did not change significantly.
Neg (not) Regulation (change) of renin in plasma
16) Confidence 0.45 Published 1976 Journal Clin Sci Mol Med Suppl Section Abstract Doc Link 1071697 Disease Relevance 0.33 Pain Relevance 0.23
Various PGs, especially PGE2 and prostacyclin (PGI2) may influence blood pressure through control of vascular tone, sodium excretion, and renin release.
Regulation (control) of renin in blood
17) Confidence 0.44 Published 1985 Journal Am. J. Kidney Dis. Section Abstract Doc Link 3922218 Disease Relevance 0.31 Pain Relevance 0.23
Twelve patients who recieved hypotensive anesthesia for surgical correction of cerebral aneurysms were studied to evaluate the role of the renin-angiotensin system in this phenomenon.
Regulation (role) of renin associated with anesthesia, cerebral aneurysm and hypotension
18) Confidence 0.44 Published 1979 Journal Anesthesiology Section Abstract Doc Link 453612 Disease Relevance 0.60 Pain Relevance 0.30
The effects of oral dilevalol (an R, R-isomer of labetalol), a new beta-adrenoceptor blocker with beta 2-receptor stimulating and alpha-recepter blocking properties on blood pressure, renal function, plasma renin activity (PRA) and plasma aldosterone have been studied in 15 patients with mild-to-moderate essential hypertension treated with it for 6 weeks.
Regulation (effects) of renin in blood associated with hypertension
19) Confidence 0.44 Published 1988 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 2905992 Disease Relevance 0.41 Pain Relevance 0.08
Intraoperative hANP infusion and postoperative treatment with aldosterone blockers and angiotensin II receptor blockers can control the renin-angiotensin-aldosterone system, inhibit left ventricular remodeling, decrease extent of infarction, and improve cardiac function, yielding a favorable long-term prognosis.
Regulation (control) of renin associated with infarction and ventricular remodeling
20) Confidence 0.44 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20691309 Disease Relevance 1.20 Pain Relevance 0.42

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