INT214073

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 20
Disease Relevance 22.00
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1)
cytoplasm (TSC1)
Anatomy Link Frequency
uterine 2
fat 1
renal artery 1
lung 1
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 98.68 Very High Very High Very High
agonist 2 97.12 Very High Very High Very High
cytokine 3 96.64 Very High Very High Very High
imagery 98 96.52 Very High Very High Very High
cva 38 94.90 High High
Inflammation 8 94.40 High High
Intractable pain 36 93.32 High High
pain flank 24 88.56 High High
Pain 4 75.40 Quite High
transdermal 2 56.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 1009 100.00 Very High Very High Very High
Tuberous Sclerosis 90 100.00 Very High Very High Very High
Skin Cancer 29 100.00 Very High Very High Very High
Anaplastic Astrocytoma 15 99.98 Very High Very High Very High
Disease 95 99.32 Very High Very High Very High
Myeloid Leukemia 334 99.26 Very High Very High Very High
Renal Cancer 126 98.90 Very High Very High Very High
Lung Cancer 56 98.28 Very High Very High Very High
INFLAMMATION 11 98.28 Very High Very High Very High
Syndrome 11 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TSC1 and TSC2 are usually considered as a complex with one function.
TSC1 Binding (complex) of
1) Confidence 0.37 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.19 Pain Relevance 0
Binding of FIP200 to hamartin was suggested to disrupt the TSC protein complex formation [40].
TSC Binding (formation) of
2) Confidence 0.27 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.44 Pain Relevance 0
Oral sirolimus therapy can also induce regression of astrocytomas associated with TSC.
TSC Binding (associated) of associated with anaplastic astrocytoma
3) Confidence 0.24 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.87 Pain Relevance 0.03
Parameters including age, sex, tumor size, multiplicity, radiologic characteristics, association with TSC, and treatment modalities were retrospectively reviewed.
TSC Binding (association) of associated with cancer
4) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 1.48 Pain Relevance 0.21
The fact that smal-sized AMLs with scant fat components and those associated with TSC may evade radiographic diagnosis is of clinical significance.
TSC Binding (associated) of in fat
5) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 0.55 Pain Relevance 0.04
Renal AMLs occupy 1-3% of renal tumors and occur in 2 clinical spectrums: sporadic and those associated with TSC.8 TSC is an autosomal disease entity with various characteristics such as mental retardation, adenoma sebaceum, seizure, renal manifestations, and loss of heterozygosity of TSC1 and TSC2 genes.4,9 Although AML is uncommon among the general population, previous studies has shown that 20% of patients with TSC are known to develop AML while on the other hand, more than 50% of AMLs are associated with TSC.7 In this rare setting, tumors tend to be larger, develop earlier in life, and are more often multiple or bilateral.3
TSC Binding (associated) of associated with myeloid leukemia, convulsion, intellectual impairment, cancer, tuberous sclerosis, renal cancer and disease
6) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 1.21 Pain Relevance 0
Although surgical intervention such as NSS or radical nephrectomy was the mainstay in the management of most renal tumors, our study demonstrated an surging number of angioembolization in patients with TSC-association.
TSC Binding (association) of associated with renal cancer
7) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 0.88 Pain Relevance 0.04
Renal AMLs occupy 1-3% of renal tumors and occur in 2 clinical spectrums: sporadic and those associated with TSC.8 TSC is an autosomal disease entity with various characteristics such as mental retardation, adenoma sebaceum, seizure, renal manifestations, and loss of heterozygosity of TSC1 and TSC2 genes.4,9 Although AML is uncommon among the general population, previous studies has shown that 20% of patients with TSC are known to develop AML while on the other hand, more than 50% of AMLs are associated with TSC.7 In this rare setting, tumors tend to be larger, develop earlier in life, and are more often multiple or bilateral.3
TSC Binding (associated) of associated with myeloid leukemia, convulsion, intellectual impairment, cancer, tuberous sclerosis, renal cancer and disease
8) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 1.21 Pain Relevance 0
A significant shift was found towards angioembolization in patients with TSC-association (p < 0.001).
TSC Binding (association) of
9) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 0.94 Pain Relevance 0.13
In conclusion, significant differences in clinical manifestations and treatment outcomes of AML were noted according to tumor size, association with TSC, multiplicity, radiologic characteristics, and treatment modalities.
TSC Binding (association) of associated with myeloid leukemia and cancer
10) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 0.66 Pain Relevance 0.03
4 cm were more commonly symptomatic, associated with TSC, and occurred in younger patients. 82 patients with tumors < 4 cm were mostly treated by NSS (n = 61, 92.4%).
TSC Binding (associated) of associated with cancer
11) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 1.22 Pain Relevance 0.04
Renal manifestations include AML, benign cyst, and renal cell carcinoma (RCC), which is the leading cause of morbidity and mortality in these patients.4 Although clinically-insignificant AMLs can be safely observed, intervention is recommended for intractable pain, large size, suspicion of malignancy, and risk of life-threatening hemorrhages.5-7 Given the benign nature of AML, renal preserving treatment modalities such as nephron-sparing surgery (NSS) or selective renal artery angioembolization are preferred.6 To set a strategy for AML management, clinical prognosis according to tumor size, association with TSC, multiplicity, radiologic finding, and treatment modality were investigated.


TSC Binding (association) of in renal artery associated with malignant neoplastic disease, myeloid leukemia, cancer, intractable pain, renal cancer, cyst and cva
12) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 1.68 Pain Relevance 0.17
Parameters including age, sex, tumor size, multiplicity, radiographic characteristics, association with TSC, and treatment modality were reviewed.


TSC Binding (association) of associated with cancer
13) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2908871 Disease Relevance 1.69 Pain Relevance 0.22
Several features differentiated patients with single AMLs from those with multiple AMLs including age, presence of symptoms, tumor size, and association with TSC.
TSC Binding (association) of associated with cancer
14) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 1.07 Pain Relevance 0
Significant differences in clinical manifestations and treatment outcomes were noted in respect to tumor characteristics, association with TSC, and treatment modality.
TSC Binding (association) of associated with cancer
15) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2908871 Disease Relevance 1.11 Pain Relevance 0.16
DNA hypermethylation is recognized as an important mechanism for tumor suppressor gene inactivation in cancer and could yield powerful biomarkers for early detection of lung cancer.
tumor suppressor Binding (recognized) of in lung associated with lung cancer and cancer
16) Confidence 0.04 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2483990 Disease Relevance 1.27 Pain Relevance 0
, the integrity of the tumor suppressor APC might be essential to guarantee PPAR?
tumor suppressor Binding (integrity) of associated with cancer
17) Confidence 0.02 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.69 Pain Relevance 0.05
The tumor suppressor gene CYLD, which was recently identified as the cylindromatosis gene, has a deubiquitinating enzyme (DUB) activity and inhibits activation of the transcription factor NF-?
tumor suppressor Binding (inhibits) of associated with cancer and skin cancer
18) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.43 Pain Relevance 0.14
Preliminary data is suggestive of a possible association between uterine PEComa and the tuberous sclerosis complex (TSC).
TSC Binding (association) of in uterine associated with tuberous sclerosis
19) Confidence 0.01 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2278149 Disease Relevance 1.41 Pain Relevance 0.08
Other selectively noteworthy findings in uterine PEComas include their 9.1% association with TSC, their occasional occurrence in young patients [23,29,34], and their occasional display of metastases in the absence of significant tumor mitotic activity [23,29].
TSC Binding (association) of in uterine associated with cancer and metastasis
20) Confidence 0.01 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2278149 Disease Relevance 1.00 Pain Relevance 0

General Comments

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