INT214106

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 3.68
Pain Relevance 7.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cartpt) extracellular region (Cartpt)
Anatomy Link Frequency
arcuate nucleus 4
hypothalamus 3
nerve 1
brain 1
afferent neurons 1
Cartpt (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 864 100.00 Very High Very High Very High
cocaine 61 100.00 Very High Very High Very High
medulla 541 99.58 Very High Very High Very High
Kinase C 20 98.28 Very High Very High Very High
gABA 96 98.20 Very High Very High Very High
antagonist 224 94.52 High High
Intracerebroventricular 18 94.40 High High
vagus nerve 84 94.12 High High
Locus ceruleus 32 93.80 High High
Thalamus 24 92.52 High High
Disease Link Frequency Relevance Heat
Appetite Loss 129 100.00 Very High Very High Very High
Aids-related Complex 52 99.68 Very High Very High Very High
Anorexia 168 99.56 Very High Very High Very High
Eating Disorder 12 99.36 Very High Very High Very High
Generalized Anxiety Disorder 24 98.80 Very High Very High Very High
Ganglion Cysts 8 98.64 Very High Very High Very High
Thinness 24 92.88 High High
Obesity 709 91.68 High High
Sleep Disorders 8 85.44 High High
Hyperphagia 37 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The action of CCK on CART expression was shown to be mediated by activation of protein kinase C and cAMP response element binding protein (CREB) and was inhibited by orexigenic ghrelin [25].
Gene_expression (expression) of CART associated with kinase c and cholecystokinin
1) Confidence 0.73 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.15 Pain Relevance 0.70
However, recently, CART expression in rat vagal afferent neurons was found negligible after 24-hour fasting, up-regulated by CCK, and restored after re-feeding.
Gene_expression (expression) of CART in afferent neurons associated with cholecystokinin
2) Confidence 0.73 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.22 Pain Relevance 0.81
In this study, the Fos immunoreactivity after injection of the CART peptide or/and CCK-8 was determined in NTS, PVN, and DMH, common targets of CART peptide [21,22] and CCK [5,15-18], in the identical set of mice.
Gene_expression (injection) of CART peptide associated with medulla and cholecystokinin
3) Confidence 0.64 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.65
Fos immunoreactivity in NTS, PVN, and DMH after CART peptide and CCK administration
Gene_expression (administration) of CART peptide associated with medulla and cholecystokinin
4) Confidence 0.64 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.55
The long lasting effect of synergistic action of CCK and the CART peptide in this study could be interpreted according to de Lartigue et al. [25] as a result of CCK- induced expression of CART and a consequent effect of the endogenously produced CART peptide after the exogenous CART peptide was exhausted.
Gene_expression (expression) of CART associated with cholecystokinin
5) Confidence 0.57 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.23 Pain Relevance 0.68
A similar, but statistically insignificant increase was observed after i.c.v. infusion of CART(61-102) (0.1 ?
Gene_expression (infusion) of CART
6) Confidence 0.55 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.57
The long lasting effect of synergistic action of CCK and the CART peptide in this study could be interpreted according to de Lartigue et al. [25] as a result of CCK- induced expression of CART and a consequent effect of the endogenously produced CART peptide after the exogenous CART peptide was exhausted.
Gene_expression (produced) of CART peptide associated with cholecystokinin
7) Confidence 0.50 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.24 Pain Relevance 0.71
Besides the well-known suppression of the orexigenic effect of NPY by CART peptide [11,28], CART peptide-induced hypophagia and brain c-Fos expression was prevented by blocking central receptors for glucagon-like peptide 1 (GLP-1) [29].
Gene_expression (expression) of CART peptide in brain associated with appetite loss
8) Confidence 0.50 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.23 Pain Relevance 0.54
There was no difference in the expressions of Pomc and Cart between two groups under the fasted condition (Figure 5).


Gene_expression (expressions) of Cart
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859050 Disease Relevance 0.16 Pain Relevance 0.16
These include POMC neurones that co-express CART and AgRP neurones that co-express NPY.
Gene_expression (express) of CART
10) Confidence 0.21 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0 Pain Relevance 0.08
For example, in hypothalamic explant experiments injection of MCH into the hypothalamus increased the production of NPY and AgRP and decreased the production of MSH and CART, as measured by radioimmunoassay [153].


Gene_expression (production) of CART in hypothalamus
11) Confidence 0.21 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.14 Pain Relevance 0.18
POMC/CART and NPY/AgRP neuronal pathways from the arcuate nucleus
Gene_expression (neuronal) of CART in arcuate nucleus
12) Confidence 0.18 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.13 Pain Relevance 0.11
Overall this gives a picture of a rather tonic anorexic signal from the POMC/CART neurones, perhaps with a more finely tuned and responsive orexigenic signal from the AgRP/NPY system?
Gene_expression (neurones) of CART associated with anorexia
13) Confidence 0.18 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.25 Pain Relevance 0.06
POMC/CART and NPY/AgRP neuronal pathways from the arcuate nucleus
Gene_expression (/) of CART in arcuate nucleus
14) Confidence 0.18 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.13 Pain Relevance 0.11
Both the POMC/CART and NPY/AgRP pathways express LEPRB and project to the leptin-dependent regions in the DMH, PVN and lateral hypothalamus (Table 1).
Gene_expression (express) of CART in hypothalamus
15) Confidence 0.18 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.03
Studies utilising immuno-electron microscopy, immunocytochemistry and in-situ hybridisation show that both the NPY/AgRP nerve fibres and the CART/POMC neurones are innervated by glutaminergic fibres too [67,68].
Gene_expression (fibres) of CART in nerve
16) Confidence 0.18 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.42 Pain Relevance 0.48
This is associated with activation of orexin neurones (but not MCH) in the lateral hypothalamus and the activation of the NPY/AgRP projection and inhibition of the POMC/CART projection in the Arc [176].
Gene_expression (projection) of CART in hypothalamus associated with aids-related complex
17) Confidence 0.18 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.18 Pain Relevance 0.67
There is also immunocytochemical evidence that orexin neurones synapse with NPY/AgRP and POMC/CART neurones in the arcuate nucleus.
Gene_expression (neurones) of CART in arcuate nucleus
18) Confidence 0.18 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.15 Pain Relevance 0.23
There is evidence from both gene and protein expression studies that the satiety neurones produce both POMC and cocaine and amphetamine regulated transcript (CART) [48].
Gene_expression (produce) of CART associated with cocaine
19) Confidence 0.16 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.10 Pain Relevance 0.09
CART arcuate nucleus neurones markedly inhibit NPY-induced feeding in fasted and normal rats [56].
Gene_expression (neurones) of CART in arcuate nucleus
20) Confidence 0.16 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.03

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