INT214160

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep, Mc4r) extracellular space (Lep) extracellular region (Lep)
plasma membrane (Mc4r) intracellular (Lep) signal transducer activity (Mc4r)
Anatomy Link Frequency
arcuate nucleus 1
brainstem 1
Lep (Mus musculus)
Mc4r (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 20 98.88 Very High Very High Very High
medulla 54 98.00 Very High Very High Very High
antagonist 20 88.72 High High
Central nervous system 30 66.24 Quite High
Cholecystokinin 16 5.00 Very Low Very Low Very Low
amygdala 16 5.00 Very Low Very Low Very Low
gABA 16 5.00 Very Low Very Low Very Low
vagus nerve 14 5.00 Very Low Very Low Very Low
Nucleus accumbens 10 5.00 Very Low Very Low Very Low
Somatostatin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anorexia 28 97.72 Very High Very High Very High
Sprains And Strains 10 83.76 Quite High
Obesity 114 78.40 Quite High
Hyperphagia 6 40.48 Quite Low
Appetite Loss 20 9.60 Low Low
Weight Gain 8 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Perhaps the MC4R receptor does integrate the anorexigenic signal from leptin via the POMC neurones of the arcuate nucleus and brainstem.
leptin Binding (integrate) of MC4R receptor in arcuate nucleus associated with medulla
1) Confidence 0.29 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.65 Pain Relevance 0.26
Perhaps the MC4R receptor does integrate the anorexigenic signal from leptin via the POMC neurones of the arcuate nucleus and brainstem.
leptin Binding (integrate) of MC4R receptor in brainstem associated with medulla
2) Confidence 0.10 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.65 Pain Relevance 0.26

General Comments

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