INT214244

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 1.24
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LAT2) intracellular (LAT2)
Anatomy Link Frequency
monocytes 2
macrophages 1
fibroblasts 1
LAT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Immobilon 1 94.44 High High
abdominal pain 12 88.44 High High
cytokine 12 80.12 Quite High
Crohn's disease 6 17.00 Low Low
monoamine 14 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
GABAergic 11 5.00 Very Low Very Low Very Low
Locus ceruleus 9 5.00 Very Low Very Low Very Low
Opioid 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Constipation 180 97.48 Very High Very High Very High
Abdominal Pain 12 88.44 High High
Diarrhoea 24 87.72 High High
Vomiting 6 87.32 High High
Colon Cancer 18 84.64 Quite High
Sprains And Strains 106 83.84 Quite High
Sleep Disorders 53 50.00 Quite Low
Pseudomonas Infection 17 50.00 Quite Low
Congenital Anomalies 10 21.20 Low Low
Inflammatory Bowel Disease 6 17.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data were further analyzed using Mat Lab (MathWorks, http://www.mathworks.com/).
Spec (analyzed) Gene_expression (using) of Lab
1) Confidence 0.65 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020497 Disease Relevance 0 Pain Relevance 0
Affinity pure F(ab)2 fragments of anti-rabbit IgG conjugated with horseradish peroxidase (Jackson Immunological Res Lab) at 1:5,000 dilution was used as secondary antibody.
Gene_expression (conjugated) of Lab
2) Confidence 0.65 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2242829 Disease Relevance 0.08 Pain Relevance 0.05
Ingested LAB produce lactate and SCFA (Short-Chain Fatty Acids), which can improve constipation via changes in intestinal microflora [20].
Gene_expression (produce) of LAB associated with constipation
3) Confidence 0.40 Published 2010 Journal Nutr J Section Body Doc Link PMC2835640 Disease Relevance 0.15 Pain Relevance 0
We collected fecal samples from the subjects both before entering and after ending the trial, to investigate LAB levels and harmful enzyme activity.
Spec (investigate) Gene_expression (levels) of LAB
4) Confidence 0.35 Published 2010 Journal Nutr J Section Body Doc Link PMC2835640 Disease Relevance 0.31 Pain Relevance 0.08
Clinical trials, fecal LAB levels and harmful enzyme activities test were done by HMA, EHB, SJ, DKL, MJK and JRK.
Gene_expression (levels) of LAB
5) Confidence 0.34 Published 2010 Journal Nutr J Section Body Doc Link PMC2835640 Disease Relevance 0.30 Pain Relevance 0
We also found that fecal LAB levels were significantly increased from 4.4 log10 CFU/g to 7.3 log10 CFU/g after LAB treatment (p = 0.024).
Gene_expression (levels) of LAB
6) Confidence 0.34 Published 2010 Journal Nutr J Section Body Doc Link PMC2835640 Disease Relevance 0.07 Pain Relevance 0
Fecal LAB levels
Gene_expression (levels) of LAB
7) Confidence 0.34 Published 2010 Journal Nutr J Section Body Doc Link PMC2835640 Disease Relevance 0.33 Pain Relevance 0.09
For this reason, we analyzed the questionnaire and tested the fecal LAB levels and harmful enzyme activities during the trials.
Gene_expression (levels) of LAB
8) Confidence 0.34 Published 2010 Journal Nutr J Section Body Doc Link PMC2835640 Disease Relevance 0 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of LAT2 in monocytes
9) Confidence 0.30 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Hence, whereas a normal expression of SLC7A6/y+LAT2 can compensate for the mutation of SLC7A7/y+LAT1 in LPI fibroblasts, the prevailing expression of y+LAT1 in monocytes and AM explains the typical LPI tissue-specific transport defect in these cells.
Gene_expression (expression) of LAT2 in monocytes
10) Confidence 0.30 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.04
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of LAT2 in macrophages
11) Confidence 0.10 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of LAT2 in fibroblasts
12) Confidence 0.10 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0

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