INT2144

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Context Info
Confidence 0.74
First Reported 1978
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 36
Total Number 36
Disease Relevance 20.92
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
fibroblasts 6
hepatocytes 2
nucleus 2
urine 2
connective tissue 2
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 44 100.00 Very High Very High Very High
rheumatoid arthritis 15 99.58 Very High Very High Very High
Snapping jaw 12 99.20 Very High Very High Very High
metalloproteinase 83 99.14 Very High Very High Very High
Inflammation 230 98.56 Very High Very High Very High
Chronic pancreatitis 35 97.76 Very High Very High Very High
carpal tunnel syndrome 2 97.04 Very High Very High Very High
Paracetamol 7 95.40 Very High Very High Very High
cytokine 45 94.84 High High
Osteoarthritis 209 94.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 328 100.00 Very High Very High Very High
Pressure And Volume Under Development 20 100.00 Very High Very High Very High
Alzheimer's Dementia 2 100.00 Very High Very High Very High
Hypersensitivity Vasculitis 2 100.00 Very High Very High Very High
Collagen Disease 1 100.00 Very High Very High Very High
Death 24 99.96 Very High Very High Very High
Syndrome 33 99.92 Very High Very High Very High
Rheumatoid Arthritis 15 99.58 Very High Very High Very High
Pulmonary Hypertension 82 99.52 Very High Very High Very High
Cancer 179 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present report we suggest that the important stretch response of collagen made possible by collagen crimping is altered by morphologic changes in disc architecture during aging and degeneration.
Localization (response) of collagen associated with aging
1) Confidence 0.74 Published 2002 Journal BMC Musculoskelet Disord Section Body Doc Link PMC101374 Disease Relevance 0.19 Pain Relevance 0
Immunolocalization of collagen types in the subsynovial connective tissue within the carpal tunnel in humans.
Localization (Immunolocalization) of collagen in connective tissue associated with carpal tunnel syndrome
2) Confidence 0.70 Published 2005 Journal J. Orthop. Res. Section Title Doc Link 15921875 Disease Relevance 0.45 Pain Relevance 0.08
It showed a statistically significant influence of burst TENS on new collagen production, maturation of newly formed collagen and organisation of collagen.
Localization (organisation) of collagen
3) Confidence 0.70 Published 2005 Journal Acta Orthop Belg Section Abstract Doc Link 16035709 Disease Relevance 0.07 Pain Relevance 0.29
In vitro release of collagen into the medium by steady-state confluent human FIB cultures was assessed over a 24-hour period by 3H-proline incorporation into collageneous protein.
Localization (release) of collagen in FIB
4) Confidence 0.67 Published 1998 Journal Eur Surg Res Section Abstract Doc Link 9493694 Disease Relevance 0.30 Pain Relevance 0.10
Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing.
Localization (secretion) of Collagen in fibroblasts associated with ulcers
5) Confidence 0.67 Published 1998 Journal Eur Surg Res Section Title Doc Link 9493694 Disease Relevance 0.33 Pain Relevance 0.10
The effects of lipoxygenase metabolites on collagen secretion was small, but different in both types of FIB.
Localization (secretion) of collagen in FIB
6) Confidence 0.67 Published 1998 Journal Eur Surg Res Section Abstract Doc Link 9493694 Disease Relevance 0.33 Pain Relevance 0.14
Serum and epidermal growth factor increased collagen secretion in both types of FIB, but gastric FIB produced less collagen than skin FIB.
Localization (secretion) of collagen in skin
7) Confidence 0.67 Published 1998 Journal Eur Surg Res Section Abstract Doc Link 9493694 Disease Relevance 0.33 Pain Relevance 0.13
In this study, we used immunogold labeling to localize collagen types within the SSCT in three cadaver specimens and three patients with carpal tunnel syndrome.
Localization (localize) of collagen in SSCT associated with cadaver and carpal tunnel syndrome
8) Confidence 0.66 Published 2005 Journal J. Orthop. Res. Section Abstract Doc Link 15921875 Disease Relevance 0.45 Pain Relevance 0.10
However, in particular studies of collagen accumulation in nerves, species dependant differences have to be considered.
Localization (accumulation) of collagen in nerves
9) Confidence 0.64 Published 2010 Journal J. Neurosci. Methods Section Abstract Doc Link 20417234 Disease Relevance 0.34 Pain Relevance 0.14
Proteoglycan also provides a reservoir for growth factors, which guide collagen assembly and promote angiogenesis.12
Localization (assembly) of collagen in reservoir
10) Confidence 0.57 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615314 Disease Relevance 0.12 Pain Relevance 0
Very occasional reference is made to the presence of collagen crimps in the fibre bundles of the intra-articular disc (IAD) of the temporomandibular joint (TMJ).
Localization (presence) of collagen in IAD associated with snapping jaw
11) Confidence 0.54 Published 2000 Journal J Oral Rehabil Section Abstract Doc Link 10931254 Disease Relevance 0.17 Pain Relevance 0.17
The interaction of platelets with damaged vessel walls leads to the formation of platelet-fibrin thrombi and may also contribute to the development of atherosclerotic lesions because platelets adherent to exposed collagen release a mitogen that stimulates smooth muscle cell proliferation.
Localization (release) of collagen in platelets associated with atherosclerosis
12) Confidence 0.52 Published 1978 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 364949 Disease Relevance 0.19 Pain Relevance 0
It was also localized in fibroblasts and collagen fibres close to cancer cells.
Localization (localized) of collagen in fibroblasts associated with cancer
13) Confidence 0.38 Published 2002 Journal J. Pathol. Section Abstract Doc Link 11857496 Disease Relevance 1.46 Pain Relevance 0.19
Vitamin C is necessary for hydroxylation of proline and lysine residues in collagen polymerization and cross-linking.105 Hydroxyproline is essential for the helical stability of collagen and its subsequent secretion into the extracellular matrix, while hydroxylysine is required for collagen cross-linking and further polymerization of fibers.2 In the absence of vitamin C, collagen formation is poor, and the unhydroxylated protein is susceptible to proteolysis.135 This leads to weakness of the extracellular matrix and the clinical condition scurvy, manifested by abnormal wound healing.2
Localization (secretion) of collagen in extracellular matrix associated with scurvy and wound healing
14) Confidence 0.35 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.84 Pain Relevance 0
The Yale database has allowed us to recognize that many patients with aortic dissection do not fit any acknowledged syndrome of collagen vascular disease.
Localization (disease) of collagen associated with syndrome and hypersensitivity vasculitis
15) Confidence 0.28 Published 2008 Journal Yale J Biol Med Section Body Doc Link PMC2605304 Disease Relevance 1.22 Pain Relevance 0.04
Depending on the cell type, the cellular responses included activation, migration, proliferation, cell death, secretion of inflammatory mediators, tissue debridement, and collagen generation.
Localization (secretion) of collagen associated with inflammatory mediators and death
16) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481293 Disease Relevance 0.81 Pain Relevance 0.25
We concluded that collagen gel immobilization not only provides mechanical support to cultured hepatocytes, but also supports long-term differentiated function of the cells for metabolic studies.
Localization (immobilization) of collagen in hepatocytes
17) Confidence 0.22 Published 1994 Journal Xenobiotica Section Abstract Doc Link 8017092 Disease Relevance 0 Pain Relevance 0.31
Collagen gel immobilization: a useful cell culture technique for long-term metabolic studies on human hepatocytes.
Localization (immobilization) of Collagen in hepatocytes
18) Confidence 0.22 Published 1994 Journal Xenobiotica Section Title Doc Link 8017092 Disease Relevance 0 Pain Relevance 0.03
Fibroblasts secrete collagen to repair both the initial and the inflammation-induced damage.
Localization (secrete) of collagen in Fibroblasts associated with inflammation
19) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481293 Disease Relevance 0.80 Pain Relevance 0.14
Vitamin C is necessary for hydroxylation of proline and lysine residues in collagen polymerization and cross-linking.105 Hydroxyproline is essential for the helical stability of collagen and its subsequent secretion into the extracellular matrix, while hydroxylysine is required for collagen cross-linking and further polymerization of fibers.2 In the absence of vitamin C, collagen formation is poor, and the unhydroxylated protein is susceptible to proteolysis.135 This leads to weakness of the extracellular matrix and the clinical condition scurvy, manifested by abnormal wound healing.2
Neg (absence) Localization (absence) of collagen in extracellular matrix associated with scurvy and wound healing
20) Confidence 0.16 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.74 Pain Relevance 0

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