INT214581

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 36
Disease Relevance 21.93
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPC)
Anatomy Link Frequency
muscle 2
blood 1
stomach 1
gut 1
GYPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 38 99.44 Very High Very High Very High
Cholecystokinin 465 99.28 Very High Very High Very High
analgesia 11 98.90 Very High Very High Very High
antagonist 35 97.20 Very High Very High Very High
Versed 32 95.32 Very High Very High Very High
Morphine 32 94.64 High High
Pain 11 93.72 High High
cytokine 44 88.48 High High
Inflammation 11 88.08 High High
Inflammatory mediators 22 87.04 High High
Disease Link Frequency Relevance Heat
Gastric Motility Disorder 1155 100.00 Very High Very High Very High
Injury 280 99.90 Very High Very High Very High
Critical Illness 619 99.62 Very High Very High Very High
Burns 121 99.08 Very High Very High Very High
Respiratory Failure 38 96.84 Very High Very High Very High
Sepsis 163 96.56 Very High Very High Very High
Eating Disorder 10 96.24 Very High Very High Very High
Appetite Loss 10 95.40 Very High Very High Very High
Shock 22 94.56 High High
Pressure And Volume Under Development 11 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, 60% of the patients had delayed GE with a mean t50 of 163 ± 7 minutes and GEC of 2.9 ± 0.1.
Negative_regulation (delayed) of GE associated with gastric motility disorder
1) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 1.37 Pain Relevance 0.14
GE was delayed most in patients with burns.
Negative_regulation (delayed) of GE associated with burns and gastric motility disorder
2) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 2.23 Pain Relevance 0
Consistent with previous reports [2-5,15,17], APACHE II scores, age, length of ICU stay, blood glucose concentrations on admission, renal function, and SIMV mode of mechanical ventilation were associated with delayed GE.
Negative_regulation (delayed) of GE in blood associated with gastric motility disorder
3) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 2.11 Pain Relevance 0.07
Both opioids and benzodiazepines impair gastric motility and reduce GE [35,36].
Negative_regulation (reduce) of GE associated with gastric motility disorder and opioid
4) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 1.95 Pain Relevance 0.51
Table 2 summarises the characteristics of patients who had delayed GE.
Negative_regulation (delayed) of GE associated with gastric motility disorder
5) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 1.43 Pain Relevance 0.13
Overall, 60% of the patients had delayed GE and a mean GEC of 2.9 ± 0.1 and t50 of 163 ± 7 minutes.
Negative_regulation (delayed) of GE
6) Confidence 0.32 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2151889 Disease Relevance 0.63 Pain Relevance 0
However, it is also likely that the analgesia requirement in these patients would contribute to the impaired GE.
Negative_regulation (impaired) of GE associated with gastric motility disorder and analgesia
7) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 2.15 Pain Relevance 0.52
GE was delayed in 58% of patients with no known co-morbidity prior to their ICU admission (t50 = 167 ± 11 minutes and GEC = 2.9 ± 0.1).
Negative_regulation (delayed) of GE associated with gastric motility disorder
8) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 2.44 Pain Relevance 0
In contrast, less than a third of the patients with acute ischaemic myocardial injury had delayed GE.
Negative_regulation (delayed) of GE associated with injury and gastric motility disorder
9) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 1.90 Pain Relevance 0.50
The observation that GE was delayed in 61% of septic patients has significant clinical implications given that up to 50% of admissions to the ICU are due to sepsis and its complications [2-4].
Negative_regulation (delayed) of GE associated with gastric motility disorder and sepsis
10) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 1.92 Pain Relevance 0.23
Critical illness factors associated with delayed GE
Negative_regulation (delayed) of GE associated with critical illness and gastric motility disorder
11) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 1.43 Pain Relevance 0.13
GE was delayed in 64% (25/39) of the patients.
Negative_regulation (delayed) of GE
12) Confidence 0.04 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2246231 Disease Relevance 0.36 Pain Relevance 0.38
GE was delayed in 64% (25/39) of the patients, with a mean GEC of 2.8 ± 0.1.
Negative_regulation (delayed) of GE
13) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.30 Pain Relevance 0.09
In healthy humans, exogenous administration of CCK and PYY is associated with relaxation of the proximal stomach, inhibition of antral motor activity, stimulation of contractions localised to the pylorus, slowing of GE [1,2,4,7,11,12], and a reduction in energy intake [3,4,13-16].
Negative_regulation (reduction) of GE in stomach associated with cholecystokinin
14) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.21 Pain Relevance 0.42
Whilst plasma CCK and PYY correlated moderately with impaired GE, the pathogenetic role of these gut hormones in delayed GE requires further evaluation with specific antagonists.



Negative_regulation (impaired) of GE in gut associated with antagonist and cholecystokinin
15) Confidence 0.04 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2246231 Disease Relevance 0.23 Pain Relevance 0.38
Nutritional deprivation is likely to be relevant since inadequate nutritional support is common in critically ill patients, fasting slows GE even in healthy subjects, and fasting CCK and PYY concentrations are higher in patients with anorexia nervosa and malnutrition [21,22].
Negative_regulation (slows) of GE associated with appetite loss, critical illness, cholecystokinin and eating disorder
16) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.63 Pain Relevance 0.13
This might potentially be the result of a temperature-induced decrease in gross-efficiency (GE).
Negative_regulation (decrease) of GE
17) Confidence 0.00 Published 2007 Journal Eur J Appl Physiol Section Abstract Doc Link PMC2039810 Disease Relevance 0 Pain Relevance 0
For the entire reduction in final time of 48 s, a decrease in GE of 2% would be necessary, which was not found.
Negative_regulation (decrease) of GE
18) Confidence 0.00 Published 2007 Journal Eur J Appl Physiol Section Body Doc Link PMC2039810 Disease Relevance 0 Pain Relevance 0
To explain the entire deterioration in time trial performance in the heat, the mean decrease in GE had to be 2%.


Negative_regulation (decrease) of GE
19) Confidence 0.00 Published 2007 Journal Eur J Appl Physiol Section Body Doc Link PMC2039810 Disease Relevance 0 Pain Relevance 0
To determine the potential importance of the measured decrease in GE on time trial performance, a 20-km time trial, which was also studied by Tucker et al. (2004), was modeled by the use of the energy flow model (De Koning et al. 1999).
Negative_regulation (decrease) of GE
20) Confidence 0.00 Published 2007 Journal Eur J Appl Physiol Section Body Doc Link PMC2039810 Disease Relevance 0.05 Pain Relevance 0

General Comments

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