INT214844

Context Info Confidence 0.45 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.15 Pain Relevance 0

cytosol (CASP10) peptidase activity (CASP10) plasma membrane (CASP10)

CASP10 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 5 17.80 cytokine 2 5.00 headache 2 5.00 backache 2 5.00 alcohol 1 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Infection 36 99.32 Apoptosis 143 98.76 Opportunistic Infections 1 91.20 Fever 3 87.48 Shigella Infection 3 86.08 Repression 4 59.44 Viral Infection 2 59.28 Venezuelan Equine Encephalomyelitis 9 50.00 Togavirus Infection 2 47.60 INFLAMMATION 5 17.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression levels of Caspase 3, caspase 4, caspase 10 and lamin A/C were increased in the infected animals compared to the controls.

Positive_regulation (increased) of Gene_expression (levels) of caspase 10

1) Confidence 0.45 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.85 Pain Relevance 0

Caspase-10 is activated in the extrinsic pathway of apoptosis, and etoposide, a chemotherapeutic agent and cytotoxic drug, induces CASP10 expression in a p53-dependent manner [80,81].

Positive_regulation (induces) of Gene_expression (expression) of CASP10 associated with apoptosis

2) Confidence 0.27 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.29 Pain Relevance 0

General Comments

This test has worked.