INT214905

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PRKD1) small molecule metabolic process (PRKD1) Golgi apparatus (PRKD1)
cytoplasm (PRKD1) cytosol (PRKD1) cell proliferation (PRKD1)
PRKD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cyst 42 96.48 Very High Very High Very High
Apoptosis 64 92.56 High High
Disease 52 80.32 Quite High
Polycystic Kidney Disease 72 60.68 Quite High
Hypertrophy 2 58.24 Quite High
Diabetes Mellitus 2 57.52 Quite High
Cancer 20 50.36 Quite High
Renal Cancer 4 47.16 Quite Low
Disease Progression 8 38.20 Quite Low
Prostate Cancer 2 19.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also possible that, due to the global decrease in protein translation by mTOR inhibitors, p21 attenuation is unrelated to the effect of these drugs in PKD.
Regulation (effect) of PKD
1) Confidence 0.03 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.95 Pain Relevance 0
In the context of its putative role in PKD as an inhibitor of cystogenesis, p21 would be expected to decrease RTE cell proliferation and thus prevent cyst formation.
Regulation (role) of PKD associated with cyst
2) Confidence 0.03 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.35 Pain Relevance 0

General Comments

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