INT215025

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 7.80
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
testes 4
neurons 4
plasma 2
pituitary 2
Ghrh (Mus musculus)
Pain Link Frequency Relevance Heat
Thoracotomy 16 97.96 Very High Very High Very High
antagonist 50 92.68 High High
Somatostatin 128 83.56 Quite High
Action potential 44 81.60 Quite High
GABAergic 18 78.20 Quite High
medulla 16 74.88 Quite High
corticosteroid 2 67.24 Quite High
gABA 12 51.48 Quite High
imagery 8 19.24 Low Low
agonist 16 14.32 Low Low
Disease Link Frequency Relevance Heat
Cancer 376 100.00 Very High Very High Very High
Acromegaly 144 99.24 Very High Very High Very High
Disease 204 98.04 Very High Very High Very High
Adenoma 120 97.12 Very High Very High Very High
Carcinoid 160 96.56 Very High Very High Very High
Metastasis 120 96.40 Very High Very High Very High
Pituitary Cancer 48 96.26 Very High Very High Very High
Lung Cancer 56 96.12 Very High Very High Very High
Recurrence 8 91.72 High High
Body Weight 2 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the stimulatory effect of ghrelin on GHRH neurons occurs in both sexes.
Negative_regulation (effect) of Gene_expression (neurons) of GHRH in neurons
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.10
In the experiment shown in Fig. 7C, the inhibitors slightly diminished the firing rate of the GHRH neuron (?
Negative_regulation (diminished) of Gene_expression (neuron) of GHRH in neuron
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.25
In addition, pituitary hyperplasia, the likely cause of the preoperative enlargement in patient 2, slowly disappeared completely, as previously described in other patients under medical therapy or after complete surgical removal of the GHRH source [27, 54].
Negative_regulation (removal) of Gene_expression (source) of GHRH in pituitary associated with pituitary cancer
3) Confidence 0.37 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.71 Pain Relevance 0.04
Surgical removal of the GHRH source is obviously the treatment of choice and results in the resolution of acromegaly when no metastases are present, as we observed in the first patient with more than 20 year follow-up.
Negative_regulation (removal) of Gene_expression (source) of GHRH associated with acromegaly and metastasis
4) Confidence 0.37 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.66 Pain Relevance 0
GH secretory characteristics of two patients were investigated before removal of the GHRH source.
Spec (investigated) Negative_regulation (removal) of Gene_expression (source) of GHRH
5) Confidence 0.37 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.12 Pain Relevance 0.11
The plasma GHRH disappearance profile after removal of the tumor is shown in Fig. 7, but the GHRH concentration did not normalize.
Negative_regulation (shown) of Gene_expression (profile) of GHRH in plasma associated with cancer
6) Confidence 0.36 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.93 Pain Relevance 0.05
Fig. 2Follow-up of GH and IGF-I concentration in patient 1 after removal of the pancreatic source of GHRH.
Negative_regulation (removal) of Gene_expression (source) of GHRH
7) Confidence 0.32 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.57 Pain Relevance 0.04
g) administration in both patients, the decrease in serum GH concentration in patient 2 after GHRH (50 ?
Negative_regulation (decrease) of Gene_expression (concentration) of GHRH
8) Confidence 0.32 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.52 Pain Relevance 0
g) administration in both patients, the decrease in serum GH concentration in patient 2 after GHRH (50 ?
Negative_regulation (patient 2) of Gene_expression (concentration) of GHRH
9) Confidence 0.32 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.51 Pain Relevance 0
g) administration in both patients, the decrease in serum GH concentration in patient 2 after GHRH (50 ?
Negative_regulation (serum) of Gene_expression (concentration) of GHRH
10) Confidence 0.32 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.51 Pain Relevance 0
This could arise through a decrease in the production of gonadotrophin-releasing hormone in the hypothalamus [56], a loss of the direct neuronal hypothalamic-testicular pathway [54] or the direct effect of mutant Htt in the testes [55].
Negative_regulation (decrease) of Gene_expression (production) of gonadotrophin-releasing hormone in testes
11) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 1.14 Pain Relevance 0.03
This could arise through a decrease in the production of gonadotrophin-releasing hormone in the hypothalamus [56], a loss of the direct neuronal hypothalamic-testicular pathway [54] or the direct effect of mutant Htt in the testes [55].
Negative_regulation (loss) of Gene_expression (production) of gonadotrophin-releasing hormone in testes
12) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 1.14 Pain Relevance 0.03

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