INT215250

Context Info Confidence 0.16 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.38 Pain Relevance 0.17

cytosol (Ncf4) cytoplasm (Ncf4)

Anatomy Link Frequency plasma 1 Ncf4 (Mus musculus)

Pain Link Frequency Relevance Heat Enkephalin 1 76.44 Inflammatory response 2 66.24 Inflammation 31 60.04 Inflammatory mediators 7 22.80 midbrain 4 5.00 rheumatoid arthritis 2 5.00 opioid receptor 2 5.00 narcan 2 5.00 imagery 2 5.00 opiate 1 5.00

Disease Link Frequency Relevance Heat Disease 17 69.28 INFLAMMATION 40 65.84 Drug Induced Neurotoxicity 22 64.16 Toxicity 6 35.20 Death 6 5.00 Parkinson's Disease 4 5.00 Neurodegenerative Disease 4 5.00 Stress 3 5.00 Necrosis 2 5.00 Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex.

Localization (translocation) of p40phox in plasma

1) Confidence 0.16 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.38 Pain Relevance 0.17

General Comments

This test has worked.